Remyelinating strategies: What can be learned from normal brain development

Do we need this after a stroke? Have we demyelinated neurons in the brain? What does your doctor know about this and what is the protocol to fix it?  

And we have this research already, just needs testing humans:

Compound Created To Help Reconstruct Myelin in Multiple SclerosisDecember 2019

And this:

Gallic and vanillic acid suppress inflammation and promote myelination in an in vitro mouse model of neurodegeneration December 2018

The latest here:

Remyelinating strategies: What can be learned from normal brain development

Author links open overlay panelJohnShelestakMuhammadIrfanTara M.DeSilva

https://doi.org/10.1016/j.coph.2022.102290Get rights and content

Under a Creative Commons license

Open access

Abstract

Multiple sclerosis (MS) is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). Immunomodulatory therapies are effective in reducing relapses, however, there is no remedy for progressive disease emphasizing the need for regenerative strategies. Chronic demyelination causes axonal injury and loss which is a key component of neurodegeneration and permanent disability in MS. New oligodendrocyte progenitor cells (OPCs) proliferate in response to inflammatory demyelination representing the potential for remyelination to protect axons and preserve neuronal function. The majority of remyelinating therapies have targeted intrinsic signaling processes in oligodendrocytes to promote differentiation or utilized methods for transplantation of oligodendrocytes. Here, we discuss specific roles of microglia in contributing to normal myelin development and the significance of these functions for remyelinating strategies.