Friday, November 18, 2022

Boswellic acids as promising agents for the management of brain diseases

 Earlier research from 2019 had this line: patients who were allocated to BA group had a significant recovery in neurological function during the 1-month follow-up.

So why the hell aren't you writing a protocol on this instead of this waste of time on a systematic review?  Your mentors and senior researchers incompetently did not know about it?

Boswellic acids as promising agents for the management of brain diseases


https://doi.org/10.1016/j.lfs.2022.121196Get rights and content

Abstract

Boswellic acid (BA)s are pentacyclic triterpenic acids present in gum resin of Boswellia species (such as B. serrata and B. carterii). They possess a variety of pharmacological effects such as anti-inflammatory, anti-oxidant, and anti-excitotoxic effects. These properties may have potential therapeutic implication in neurological disorders. Notably, the BAs-induced neuroprotection is proposed to be associated with the ability to reduce neurotoxic aggregates, decrease oxidative stress, and improve cognitive dysfunction. Recently, BAs have been suggested as potential agents for the treatment of brain tumors due to their potential to attenuate cell proliferation, migration, metastasis, angiogenesis, and promote apoptosis during both in vitro and in vivo studies. The present review aims to address these studies and highlights the possible underlying mechanisms of the observed effects. Besides, novel formulations and improving pharmacokinetic properties may enhance the therapeutic efficacy of BAs.

Keywords

Boswellic acid
Neurodegenerative diseases
Brain tumor
Bioavailability

Data availability

Data will be made available on request.

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