Clathrin-Nanoparticles Efficiently Deliver BDNF to the Hippocampus, Reverse Depression and Neuroinflammation and Increase Neurogenesis, Dendritic Length and Spine Density in HIV/neuroAIDS Mouse Model

This sounds incredibly important for our recovery. What is your doctor and hospital doing to get human testing going? NOTHING?  Then you don't have a functioning stroke doctor or hospital!

• BDNF (164 posts to April 2011)

Clathrin-Nanoparticles Efficiently Deliver BDNF to the Hippocampus, Reverse Depression and Neuroinflammation and Increase Neurogenesis, Dendritic Length and Spine Density in HIV/neuroAIDS Mouse Model

• Gordana Vitaliano
• Christopher Adam
• Corvens Depaliste
• Sean Oakes
• Franco Vitaliano

DOI:https://doi.org/10.1016/j.biopsych.2023.02.199

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BDNF reverses depression and promotes neuroregeneration but cannot easily cross a blood-brain barrier (BBB). We delivered up to 400-fold higher CNS BDNF concentrations with Clathrin-nanoparticles (BC-NPs) than other delivery methods (Vitaliano, 2022). Our goal was to decrease neurotoxic/neuroinflammatory effects of HIV/transactivator of transcription (Tat) protein and reverse depression in Tat+ mice.

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