Progress in application of adult endogenous neurogenesis in brain injury repair

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Progress in application of adult endogenous neurogenesis in brain injury repair

Bai TY¹,

Mu J¹,

Hao P²,

Duan HM²,

Hao F¹,

Zhao W²,

Gao YD²,

Wang ZJ²,

Yang ZY²,

Li XG¹

Author information

Sheng li xue bao : [Acta Physiologica Sinica], 01 Apr 2023, 75(2):231-240Language:chi
PMID: 37089097 

Review

Abstract 

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Persistent neurogenesis exists in the subventricular zone (SVZ) of the ventricles and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus in the adult mammalian brain. Adult endogenous neurogenesis not only plays an important role in the normal brain function, but also has important significance in the repair and treatment of brain injury or brain diseases. This article reviews the process of adult endogenous neurogenesis and its application in the repair of traumatic brain injury (TBI) or ischemic stroke, and discusses the strategies of activating adult endogenous neurogenesis to repair brain injury and its practical significance in promoting functional recovery after brain injury.