Dietary nitrate intake in relation to the risk of dementia and imaging markers of vascular brain health: a population-based study

 I assume your competent doctor had you creating nitric oxide in various ways for years now.

• endothelial nitric oxide (1 post to January 2019)

• nitric oxide (111 posts to March 2011)

• nitric oxide generator (1 post to July 2022)

• nitric oxide pathways (1 post to July 2021)

• nitric oxide synthase (1 post to August 2019)

• Dietary nitrate (1 post to May 2023)

 

Dietary nitrate intake in relation to the risk of dementia and imaging markers of vascular brain health: a population-based study

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https://doi.org/10.1016/j.ajcnut.2023.05.027Get rights and content

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Referred to by

Could dietary nitrate affect dementia development?

The American Journal of Clinical Nutrition, Available online 6 July 2023, Pages

Adrián Carballo-Casla, Michelle M. Dunk, Carolina Donat-Vargas, Weili Xu

Abstract

Background

Nitric oxide is a free radical that can be produced from dietary nitrate and positively affects cardiovascular health. With cardiovascular health playing an important role in the etiology of dementia, we hypothesized a link between dietary nitrate intake and the risk of dementia.

Objectives

This study aimed to find the association of total, vegetable, and nonvegetable dietary nitrate intake with the risk of dementia and imaging markers of vascular brain health, such as total brain volume, global cerebral perfusion, white matter hyperintensity volume, microbleeds, and lacunar infarcts.

Methods

Between 1990 and 2009, dietary intake was assessed using food-frequency questionnaires in 9543 dementia-free participants (mean age, 64 y; 58% female) from the prospective population-based Rotterdam Study. Participants were followed up for incidence dementia until January 2020. We used Cox models to determine the association between dietary nitrate intake and incident dementia. Using linear mixed models and logistic regression models, we assessed the association of dietary nitrate intake with changes in imaging markers across 3 consecutive examination rounds (mean interval between images 4.6 y).

Results

Participants median dietary nitrate consumption was 85 mg/d (interquartile range, 55 mg/d), derived on average for 81% from vegetable sources. During a mean follow-up of 14.5 y, 1472 participants developed dementia. A higher intake of total and vegetable dietary nitrate was associated with a lower risk of dementia per 50-mg/d increase [hazard ratio (HR): 0.92; 95% confidence interval (CI): 0.87, 0.98; and HR: 0.92; 95% CI: 0.86, 0.97, respectively] but not with changes in neuroimaging markers. No association between nonvegetable dietary nitrate intake and the risk of dementia (HR: 1.15; 95% CI: 0.64, 2.07) or changes in neuroimaging markers were observed.

Conclusions

A higher(Ask your doctor the EXACT DEFINITION OF HIGHER!) dietary nitrate intake from vegetable sources was associated with a lower risk of dementia. We found no evidence that this association was driven by vascular brain health.