Abstract
Objective
Hospital-associated
sarcopenia is prevalent and associated with poor outcomes in acutely
admitted patients. Prevention of developing sarcopenia during
hospitalization is an important factor in stroke management. Therefore,
this study aimed to investigate whether energy intake and rehabilitation
duration contribute to the prevention of hospital-associated sarcopenia
in patients with acute stroke.
Methods
Patients
with acute stroke were included in this study. Energy intake during the
first week of hospitalization was classified as “High” or “Low” based
on the reported cutoff value. Rehabilitation time during hospitalization
was classified as “Intense” or “Mild, based on the median. The four
groups were compared based on the combination of high/low energy intake
and intense/mild rehabilitation. The primary outcome was the development
of sarcopenia during hospitalization. The secondary outcome was the
functional independence measure motor item gain during hospitalization.
Multivariate analysis was performed with the primary/secondary outcome
as the dependent variable and the effect of each group on the outcome
was examined.
Results
One
hundred and twelve participants (mean age 70.6 years, 63 men) were
included in the study. Multivariate analysis showed that
“High × Intense” (OR=0.113, p=0.041) was independently associated with
the development of sarcopenia during hospitalization (i.e.,
hospital-related sarcopenia). “High × Intense” (β=0.395, p<0.001) was
independently associated with the gain of FIM motor items.
Conclusions
In
patients with acute stroke, the combination of high-energy intake and
adequate rehabilitation time is associated with prevention of
hospital-associated sarcopenia.
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