Locus of control: How the brain gives up when failure is taken for granted

 This is precisely what happens when your doctor tells you nothing about 100% recovery.

Locus of control: How the brain gives up when failure is taken for granted

DOI:https://doi.org/10.1016/j.neuron.2023.08.013

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After repeatedly failing to get out of a stressful, uncontrollable environment, mice switch from escape behavior to inactivity. In this issue of Neuron, Li et al. identify a circuit involving noradrenergic projections from the locus coeruleus to GABAergic projection neurons in the orbitofrontal cortex that participate in this adaptive behavior.

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