Chronic caffeine consumption curbs rTMS-induced plasticity

I'm not concerned with my one 12 cup pot of coffee daily.  Neuroplasticity is not in any sense scientifically repeatable and I'm more concerned with preventing Parkinsons and dementia. 

Well, the whole reason for drinking the vast amounts of coffee I do is to prevent Parkinsons and dementia.This will not change my mind.

I'm doing a 12 cup pot of coffee a day to lessen my chance of dementia and Parkinsons. Tell me EXACTLY how much coffee to drink for that and I'll change.

How coffee protects against Parkinson’s Aug. 2014  

Coffee May Lower Your Risk of Dementia Feb. 2013 

And this: Coffee's Phenylindanes Fight Alzheimer's Plaque December 2018

How Coffee May Protect Brain Health: A New Study Suggests The Benefits Aren't Just From Caffeine December 2018

Caffeine causes widespread brain entropy (and that's a good thing)

April 2018

This Many Coffees(6) Is Bad For Your Heart Health August 2020(I'm ignoring this one)

Study: The More Coffee You Drink, the Longer You Live July 2018 

The latest here:

Chronic caffeine consumption curbs rTMS-induced plasticity

Megan Vigne¹ Jamie Kweon¹ Prayushi Sharma¹ Benjamin D. Greenberg^1,2 Linda L. Carpenter^1,2 Joshua C. Brown^1,2,3*†

• ¹Neuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United States
• ²Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, United States
• ³Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, United States

Background: Caffeine is a widely used psychostimulant. In the brain, caffeine acts as a competitive, non-selective adenosine receptor antagonist of A1 and A2A, both known to modulate long-term potentiation (LTP), the cellular basis of learning and memory. Repetitive transcranial magnetic stimulation (rTMS) is theorized to work through LTP induction and can modulate cortical excitability as measured by motor evoked potentials (MEPs). The acute effects of single caffeine doses diminish rTMS-induced corticomotor plasticity. However, plasticity in chronic daily caffeine users has not been examined.

Method: We conducted a post hoc secondary covariate analysis from two previously published plasticity-inducing pharmaco-rTMS studies combining 10 Hz rTMS and D-cycloserine (DCS) in twenty healthy subjects.

Results: In this hypothesis-generating pilot study, we observed enhanced MEP facilitation in non-caffeine users compared to caffeine users and placebo.

Conclusion: These preliminary data highlight a need to directly test the effects of caffeine in prospective well-powered studies, because in theory, they suggest that chronic caffeine use could limit learning or plasticity, including rTMS effectiveness.