Wednesday, November 22, 2023

Redefining stroke rehabilitation: Mobilizing the embodied goal-oriented brain

 This won't do a damn bit of good until you save hundreds of millions to billions of neurons in the first week by stopping the 5 causes of the neuronal cascade of death.

Do you people ever think at all?

Redefining stroke rehabilitation: Mobilizing the embodied goal-oriented brain

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https://doi.org/10.1016/j.conb.2023.102807Get rights and content
Under a Creative Commons license
open access

Highlights

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    Current poststroke rehabilitation shows limited impact and lacks scalability, questioning both its foundations and practice.

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    The latest advances in the neuroscience of stroke argue for all architecture and network perspective.

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    The adaptive mechanisms underlying the embodied, situated, and volitional brain must take center stage in rehabilitation.

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    Translation to the clinic requires system-level models such as the Distributed Adaptive Control theory of mind and brain.

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    Brain theory-informed scalable interventions, such as the Rehabilitation Gaming System, outperform standard interventions.

Abstract

Advancements in stroke rehabilitation remain limited and call for a reorientation. Based on recent results, this study proposes a network-centric perspective on stroke, positing that it not only causes localized deficits but also affects the brain's intricate network of networks, transiting it into a pathological state. Translating these system-level insights into interventions requires brain theory, and the Distributed Adaptive Control (DAC) theory offers such a framework. When applied in the rehabilitation gaming system, these principles demonstrate superior results over conventional methods. This impact stems from activating extensive brain networks, particularly the executive control network, focused motor learning, and maintaining excitatory-inhibitory balance, which is essential for neural repair and functional reorganization. The analysis stresses uniting preclinical and clinical research and placing the architecture of the embodied volitional brain at the centre of rehabilitation approaches.

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