Ask you competent? doctor if you need myelin repair post stroke, and don't accept not knowing as an answer. YOUR FUCKING DOCTOR IS SUPPOSED TO BE COMPETENT! Only over a decade for your doctor to become competent in myelin!
In here is both myelin repair topics and whether stroke causes myelin damage.
myelin (73 posts to April 2011)
Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis
Published:April 22, 2024DOI:https://doi.org/10.1016/j.neuron.2024.03.026
Highlights
- •GH treatment promotes myelin repair and functional recovery after hypoxia
- •GHR is selectively expressed by a subpopulation of pericytes
- •GHR-positive pericyte-tip cells lead blood vessel bridging and branching
- •GHR-positive pericytes modulate angiogenesis and govern myelination indirectly
Summary
White matter injury (WMI) causes oligodendrocyte precursor cell (OPC) differentiation
arrest and functional deficits, with no effective therapies to date. Here, we report
increased expression of growth hormone (GH) in the hypoxic neonatal mouse brain, a
model of WMI. GH treatment during or post hypoxic exposure rescues hypoxia-induced
hypomyelination and promotes functional recovery in adolescent mice. Single-cell sequencing
reveals that Ghr mRNA expression is highly enriched in vascular cells. Cell-lineage labeling and tracing
identify the GHR-expressing vascular cells as a subpopulation of pericytes. These
cells display tip-cell-like morphology with kinetic polarized filopodia revealed by
two-photon live imaging and seemingly direct blood vessel branching and bridging.
Gain-of-function and loss-of-function experiments indicate that GHR signaling in pericytes
is sufficient to modulate angiogenesis in neonatal brains, which enhances OPC differentiation
and myelination indirectly. These findings demonstrate that targeting GHR and/or downstream
effectors may represent a promising therapeutic strategy for WMI.
No comments:
Post a Comment