Ask your competent? doctor a simple question: Should CoQ10 supplementation be started immediately post stroke to possibly prevent your risk of Parkinsons?
The latest here:
2024-06-05
Abstract
Neurodegenerative diseases (NDDs) are a heterogeneous group of
disorders primarily affecting the central nervous system (CNS) and are
characterised by the progressive loss of neuronal structure and function
(neurodegeneration). The most common NDDs include Parkinson’s disease
(PD). PD is the second most prevalent NDD currently affecting the ageing
population. Although the aetiology of PD remains unknown, increasing
evidence has suggested that oxidative stress and impaired mitochondrial
function, specifically mitochondrial complex I deficiency, are important
pathogenic causes for neuronal degeneration in the substantia nigra
pars compacta (SNpc) of PD patients, all of which are associated with
CoQ10 deficiency. Mitochondria are essential for neuronal function;
however, these organelles are major sources of reactive oxygen species
(ROS) and are vulnerable targets for oxidative stress-induced damage.
Mitochondria-targeted antioxidant therapies have become an attractive
therapeutic strategy to ameliorate mitochondrial dysfunction and
oxidative stress in PD. Increasing evidence has shown
that CoQ10
supplementation may provide a neuroprotective effect in PD by restoring
endogenous CoQ10 levels in addition to ameliorating oxidative stress and
mitochondrial dysfunction, due to its antioxidant properties and its
ability to restore electron flow in the mitochondrial electron transport
chain (ETC). Therefore, CoQ10 supplementation may be a beneficial
therapeutic strategy to improve mitochondrial function and reduce the
severity of neurodegeneration in PD.
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