Now if you had a competent? doctor and hospital, they would ensure human testing gets done and an EXACT DIET protocol is created.
But you don't have a functioning stroke doctor or stroke hospital, do you?
Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice
Highlights
- •Cyclic KD preserves memory in aged mice even when administered later in life
- •KD improves LTP and increases dendritic tree complexity
- •KD upregulates the cAMP signaling pathway in the synaptic proteome of aged mice
- •β-Hydroxybutyrate activates PKA and stimulates BDNF expression
Summary
Aging
compromises brain function leading to cognitive decline. A cyclic
ketogenic diet (KD) improves memory in aged mice after long-term
administration; however, short-term effects later in life and the
molecular mechanisms that govern such changes remain unclear. Here, we
explore the impact of a short-term KD treatment starting at elderly
stage on brain function of aged mice. Behavioral testing and long-term
potentiation (LTP) recordings reveal that KD improves working memory and
hippocampal LTP. Furthermore, the synaptosome proteome of aged mice fed
a KD long-term evidence changes predominantly at the presynaptic
compartment associated to the protein kinase A (PKA) signaling pathway.
These findings were corroborated in vivo by western blot
analysis, with high BDNF abundance and PKA substrate phosphorylation.
Overall, we show that a KD modifies brain function even when it is
administered later in life and recapitulates molecular features of
long-term administration, including the PKA signaling pathway, thus
promoting synaptic plasticity at advanced age.
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