Wednesday, June 26, 2024

Lower extremity physical function and quality of life in patients with stroke: a longitudinal cohort study

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Lower extremity physical function and quality of life in patients with stroke: a longitudinal cohort study

written by: Michelle Ryan, Roland Rössler, Nikki Rommers, Laura Iendra, Eva-Maria Peters, Reto W. Kressig, Arno Schmidt-Trucksäss, Stefan T. Engelter, Nils Peters, Timo Hinrichs

Appeared in: Quality of Life Research

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Abstract

Purpose

Lower extremity physical function (LEPF) is a key component for mobility and is impacted in stroke-related disability. A reduction in LEPF can have a significant impact on an individual’s Quality of Life (QoL). The aim of this study is to characterise the relationship between LEPF and QoL.

Methods

The MOBITEC-Stroke Study is a longitudinal cohort-study including patients with their first occurrence of ischaemic stroke. Using a linear mixed-effects model, the relationship between LEPF (timed up-and-go performance (TUG); predictor) and QoL (Stroke Specific Quality of Life scale (SS-QoL); outcome) at 3 and 12 months post stroke was investigated and adjusted for sex, age, Instrumental Activities Daily Living (IADL), fear of fallingSeverrokeality scale, NIHSS), accounting for the repeated measurements.

Results

Data of 51 patients (65% males, 35% females) were analysed. The mean age was 71.1 (SD 10.4) years, median NIHSS score was 2.0. SS-QoL was 201.5 (SD 20.5) at 3 months and 204.2 (SD 17.4) at 12 months; the mean change was 2.7 (95% CI -2.4 to 7.7), p 0.293. A positive association was found between baseline TUG performance (estimate log score -13.923; 95% CI -27.495 to -0.351; p-0.048) and change in SS-QoL score in multivariate regression analysis.

Conclusion

Higher LEPF (i.e better TUG performance) at baseline, was associated with an improvement in QoL from 3- to 12-months post stroke. These results highlight the critical role of physical function, particularly baseline LEPF, in influencing the QoL of stroke survivors.

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