100% recovery is a giant leap, anything less is miniscule. The only goal in stroke is 100% recovery. Does this get us there?
Small Step or Giant Leap? Expanding the Acute Stroke Thrombolysis Window to 24 Hours
Published June 14, 2024
DOI: 10.1056/NEJMe2405846
Abstract
Intravenous tenecteplase has been shown to be noninferior to alteplase, with a meta-analysis suggesting superiority,1
and although tenecteplase has been used off label, it is replacing
alteplase as the preferred thrombolytic agent for the treatment of acute
stroke. Aside from the use of thrombolysis for stroke on awakening
(which applies to a limited population of patients with restrictive use
involving the immediate need for magnetic resonance imaging to assess
for mismatch between findings on diffusion-weighted imaging and those on
fluid-attenuated inversion recovery imaging), thrombolysis for the
treatment of acute stroke has generally remained confined to the
4.5-hour time window after . . .
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