The effect of inadvertent systemic hypothermia after mechanical thrombectomy in patients with large-vessel occlusion stroke

 What protocol is your competent? hospital following in this until further research is done? Do they even have ANY PROTOCOLS FOR STROKE?

The effect of inadvertent systemic hypothermia after mechanical thrombectomy in patients with large-vessel occlusion stroke

Kristina auf dem Brinke¹Fabian Kück²Ala Jamous³Marielle Ernst³Nils Kunze-Szikszay⁴Marios-Nikos Psychogios⁵Ilko L. Maier^1*

• ¹Department of Neurology, University Medical Center Göttingen, Göttingen, Germany
• ²Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany
• ³Department of Neuroradiology, University Medical Center Göttingen, Göttingen, Germany
• ⁴Department of Anesthesiology, University Medical Center Göttingen, Göttingen, Germany
• ⁵Department of Neuroradiology, Universitätsspital Basel, Basel, Switzerland

Background and aims: Postinterventional hypothermia is a frequent complication in patients with large-vessel occlusion strokes (LVOS) after mechanical thrombectomy (MT). This inadvertent hypothermia might potentially have neuroprotective but also adverse effects on patients’ outcomes. The aim of the study was to determine the rate of hypothermia in patients with LVOS receiving MT and its influence on functional outcome.

Methods: We performed a monocentric, retrospective study using a prospectively derived databank, including all LVOS patients receiving MT between 2015 and 2021. Predictive values of postinterventional body temperature and body temperature categories (hyperthermia (≥38°C), normothermia (35°C–37.9°C), and hypothermia (<35°C)) on functional outcome were analyzed using multivariable Bayesian logistic regression models. Favorable outcome was defined as modified Rankin Scale (mRS) ≤3.

Results: Of the 480 included LVOS patients with MT (46.0% men; mean ± SD age 73 ± 12.9 years), 5 (1.0%) were hyperthermic, 382 (79.6%) normothermic, and 93 (19.4%) hypothermic. Postinterventional hypothermia was significantly associated with unfavorable functional outcome (mRS > 3) after 90 days (OR 2.06, 95% CI 1.01–4.18, p = 0.045). For short-term functional outcome, patients with hypothermia had a higher discharge NIHSS (OR 1.38, 95% CI 1.06 to 1.79, p = 0.015) and a higher change of NIHSS from admission to discharge (OR 1.35, 95% CI 1.03 to 1.76, p = 0.029).

Conclusion: Approximately a fifth of LVOS patients in this cohort were hypothermic after MT. Hypothermia was an independent predictor of unfavorable functional outcomes. Our findings warrant a prospective trial(WHO EXACTLY ARE YOU CONTACTING TO GET THIS FURTHER RESEARCH DONE? NOBODY? So you're incompetent?) investigating active warming during MT.