FYI. Your doctor should know about this.
Brain responses to intermittent fasting and the healthy living diet in older adults
Published:June 19, 2024DOI:https://doi.org/10.1016/j.cmet.2024.05.017
Highlights
- •8 weeks of 5:2 intermittent fasting caused more weight loss than healthy living diet
- •Both diets reduced neuronal insulin resistance and the pace of brain aging
- •Both diets improved memory and executive function, with 5:2 intermittent fasting more so
- •Biomarkers of Alzheimer’s disease did not change with either diet
Summary
Diet may promote brain health in metabolically impaired older individuals. In an 8-week
randomized clinical trial involving 40 cognitively intact older adults with insulin
resistance, we examined the effects of 5:2 intermittent fasting and the healthy living
diet on brain health. Although intermittent fasting induced greater weight loss, the
two diets had comparable effects in improving insulin signaling biomarkers in neuron-derived
extracellular vesicles, decreasing the brain-age-gap estimate (reflecting the pace
of biological aging of the brain) on magnetic resonance imaging, reducing brain glucose
on magnetic resonance spectroscopy, and improving blood biomarkers of carbohydrate
and lipid metabolism, with minimal changes in cerebrospinal fluid biomarkers for Alzheimer’s
disease. Intermittent fasting and healthy living improved executive function and memory,
with intermittent fasting benefiting more certain cognitive measures. In exploratory
analyses, sex, body mass index, and apolipoprotein E and SLC16A7 genotypes modulated diet effects. The study provides a blueprint for assessing brain
effects of dietary interventions and motivates further research on intermittent fasting
and continuous diets for brain health optimization. For further information, please
see ClinicalTrials.gov registration: NCT02460783.
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