Blood–Brain Barrier Disruption and Imaging Assessment in Stroke

 My God, we've known of this problem forever! You're fired for not even trying to solve it, including your mentors and senior researchers! A vast amount of dead wood needs to be removed in stroke, put me in charge and there will be a bloodbath of firing! There are no excuses for such incompetency!

• blood brain barrier (162 posts to March 2011)

Blood–Brain Barrier Disruption and Imaging Assessment in Stroke

• Yuchen Liang,
• Yueluan Jiang,
• Jiaxin Liu,
• Xuewei Li,
• Xinyue Cheng,
• Lei Bao,
• Hongwei Zhou &
• Zhenni Guo 

• 23 Accesses

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Abstract

Disruption of the blood–brain barrier (BBB) is an important pathological hallmark of ischemic stroke. Blood–brain barrier disruption (BBBD) is a consequence of ischemia and may also exacerbate damage to brain parenchyma. Therefore, maintaining BBB integrity is critical for the central nervous system (CNS) homeostasis. This review offers a concise overview of BBB structure and function, along with the mechanisms underlying its impairment following a stroke. In addition, we review the recent imaging techniques employed to study blood–brain barrier permeability (BBBP) in the context of ischemic brain injury with the goal of providing imaging guidance for stroke diagnosis and treatment from the perspective of the BBBD. This knowledge is vital for developing strategies to safeguard the BBB during cerebral ischemia.