The
importance of complex systems has become increasingly evident in recent
years. The nervous system is one such example with neural networks
sitting at the intersection of complex networks and biology. A
particularly exciting feature is the resilience of complex systems. For
example, the ability of the nervous system to perform even in the face
of challenges(HOW WILL YOUR COMPETENT? DOCTOR ENSURE THIS WILL OCCUR?)that include neuronal loss, neuroinflammation, protein
accumulation, axonal disruptions, and metabolic stress is an intriguing
and exciting line of investigation. In neurodegenerative diseases,
neural network resilience is responsible for the time between the
earliest disease-linked changes and clinical symptom onset and disease
diagnosis. In this way, connectivity resilience of neurons within the
complex network of cells that make up the nervous system has significant
implications. This review provides an overview of relevant concepts
related to complex systems with a focus on the connectivity of the
nervous system. It discusses the development of the neural network and
how a delicate balance determines how this complex system responds to
injury with examples illustrating maladaptive plasticity. The review
then addresses the implications of these concepts, methods to understand
brain connectivity and neural networks, and recent research efforts
aimed at understanding neurodegeneration from this perspective. The
authors aim to provide foundational knowledge and an overview of current
research directions in this evolving and exciting area of neuroscience.
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