Association of serum uric acid to serum creatinine ratio with 1-year stroke outcomes in patients with acute ischemic stroke: A multicenter observational cohort study

 You described a stroke risk factor but provided NOTHING to prevent the risk! Useless. 

Association of serum uric acid to serum creatinine ratio with 1-year stroke outcomes in patients with acute ischemic stroke: A multicenter observational cohort study

Dandan Zhang  ^{1   2} , Zhongzhong Liu  ^{1   2   3} , Weiyan Guo  ² , Qingli Lu  ^{1   2} , Zhen Lei  ⁴ , Pei Liu  ^{1   2} , Tong Liu  ^{1   2} , Linna Peng  ^{1   2} , Qiaoqiao Chang  ^{1   2} , Mi Zhang  ^{1   2} , Xuemei Lin  ^{1   2} , Fang Wang  ^{1   2} , Songdi Wu  ^{1   2   4}

Affiliations

• PMID: 39104135
• PMCID: PMC11555002
• DOI: 10.1111/ene.16431

Abstract

Background and purpose: Considering the reliance of serum uric acid (SUA) levels on renal clearance function, its role in stroke outcomes remains controversial. This study investigated the association of renal function-normalized SUA (SUA to serum creatinine ratio, SUA/SCr), a novel renal function index, with the 1-year outcomes in patients with acute ischemic stroke (AIS).

Methods: This is a prospective, multicenter observational study. Renal function-normalized SUA levels were determined by calculating the ratio of SUA to SCr. One-year outcomes included stroke recurrence, all-cause mortality, and poor prognosis. Multivariable Cox regression analyses and restriction cubic splines for curve fitting were used to evaluate SUA/SCr's association with 1-year stroke outcomes.

Results: Among 2294 enrolled patients, after adjustment for potential confounders, multivariable Cox regression analyses showed that each one-unit increase in SUA/SCr corresponded to a 19% decrease in 1-year stroke recurrence in patients with AIS. SUA/SCr was analyzed as a continuous variable and categorized into quartiles (Q1-Q4). Compared with the Q1 reference group, Q2, Q3, and Q4 showed significantly lower 1-year stroke recurrence risks. The trend test indicated significant differences in the 1-year stroke recurrence trend from Q1 to Q4. In these patients, SUA/SCr did not show a significant association with poor prognosis or all-cause mortality. Curve fitting revealed SUA/SCr had a negative but nonlinear association with 1-year stroke recurrence.

Conclusions: In patients with AIS, low SUA/SCr may be an independent risk factor for 1-year stroke recurrence. Changes in SUA/SCr had no significant impact on 1-year poor prognosis and all-cause mortality.

Keywords: acute ischemic stroke; renal function; serum creatinine; serum uric acid; stroke outcomes.

© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

PubMed Disclaimer