Is your doctor and stroke hospital so FUCKING INCOMPETENT THEY DIDN'T CREATE AND INSTALL A PROTOCOL ON THIS YEARS AGO?
Do you prefer your doctor and hospital incompetence being NOT KNOWING. Or NOT DOING?
And much earlier, this might be
leg wraps (9 posts to May 2013)
leg compressions (19 posts to September 2015)
Effect of RICAS (Remote Ischemic Preconditioning on Collaterals of Atherosclerosis Stroke): Rationale and Design
Abstract
Background
As
a noninvasive, low‐cost, nonpharmacological procedure with excellent
properties of safety, remote ischemic conditioning (RIC) has been
demonstrated to prevent recurrence of stroke among patients with
ischemic stroke of large artery atherosclerosis origin. We hypothesized
that the benefit is attributed to the improvement of collaterals by
chronic RIC in this population, and we aimed to explore the influence of
chronic RIC on collateral status evaluated by digital subtraction
angiography in this population.
Methods
The
RICAS (Remote Ischemic Preconditioning on Collaterals of
Atherosclerosis Stroke) study is a prospective, randomized, blind end
point, multicenter study. Eligible patients with ischemic stroke of
anterior circulation caused by large artery atherosclerosis, poor
collateral compensation, and more than 1 month of symptom onset, are
randomly assigned into experimental and control groups with a ratio of
1:1. The patients in the experiment group will receive treatment with
RIC (bilateral upper limbs, for a total procedure time of 50 minutes,
twice daily) for 1 year as an adjunct to guideline‐based treatment,
while patients in the control group only receive guideline‐based
treatment. A maximum of 300 patients (150 participants per group) are
required to test the superiority hypothesis with 80% power (using a
2‐sided α=0.05) to detect a 15% difference. Subgroup analyses for
the primary end point will be performed on 8 prespecified subgroups by
age, sex, ischemic event (acute ischemic stroke ore transient ischemic
stroke), tandem lesion, history of hypertension, hypercholesterolemia,
diabetes, and myocardial infarction. The primary outcome is the
proportion of collateral status improvement, which is defined as an
increase of ≥1 point on the American Society of Interventional and
Therapeutic Neuroradiology/Society of Interventional Radiology score, as
assessed by digital subtraction angiography at 12 months after
randomization. The safety outcomes include RIC‐related adverse events.
Conclusions
This
study may provide the direct evidence for the potential effect of
chronic RIC treatment on the improvement of collateral status.
Registration
URL: https://clinicaltrials.gov. Unique identifier: NCT06170944.
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