Ask your competent? doctor if this is enough to UNDERSTAND EXACTLY HOW TO MAKE NEUROGENESIS REPEATABLE ON DEMAND! And then CREATE PROTOCOLS TO DO THAT!
Your competent? stroke medical 'professionals' have been working on mitochondrial fission for over a decade, right? Oh NO! You just realized the whole stroke medical world is FUCKING INCOMPETENT! Your solution is to not have a stroke! - mitochondrial fission
(1 post to November 2013)
Mitochondrial and peroxisomal fission in cortical neurogenesis
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Introduction
The
human brain is unique in its cellular diversity, intricate
cytoarchitecture, function, and complex metabolic and bioenergetic
demands, for which mitochondria and peroxisomes are essential.
Mitochondria are multifunctional organelles that coordinate various
signaling pathways central to neurogenesis. The dynamic morphological
changes of the mitochondrial network have been linked to the regulation
of bioenergetic and metabolic states. Specific protein machinery is
dedicated to mitochondrial fission and fusion, allowing organelle
distribution during cell division, organelle repair, and adaptation to
environmental stimuli (excellent reviews have been published on these
topics [Kondadi & Reichert 2024; Giacomello et al. 2020; Tilokani et
al. 2018; Kraus et al. 2021; Navaratnarajah et al. 2021]). In parallel,
peroxisomes contain over 50 different enzymes which regulate metabolic
functions that are critical for neurogenesis (Berger et al., 2016,
Hulshagen et al., 2008). Peroxisomes share many of the components of
their fission machinery with the mitochondria and undergo fission to
help meet metabolic demands in response to environmental stimuli
(Schrader et al. 2016). This review focuses primarily on the machinery
involved in mitochondrial and peroxisomal fission. Mitochondrial fission
has been identified as a critical determinant of cell fate decisions
(Iwata et al., 2023, Iwata et al., 2020, Khacho et al., 2016, King et
al., 2021, Prigione and Adjaye, 2010, Vantaggiato et al., 2019, Kraus et
al., 2021). The connection between alterations in peroxisomal fission
and metabolic changes associated with cellular differentiation remains
less clear. Here, we provide an overview of the functional and
regulatory aspects of the mitochondrial and peroxisomal fission
machinery and provide insight into the current mechanistic understanding
by which mitochondrial and peroxisomal fission influence neurogenesis.
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