We don't need more useless prediction of bad outcomes. Do the damn research that prevents those outcomes!
Association of neutrophil-to-lymphocyte ratio with stroke morbidity and mortality: evidence from the NHANES 1999–2020Xin Xu1†, Guoqiang Zhang2,3,4†, Fei Liu3,4,5†, Jingwei Zheng2,3,4, Zhijie Jiang2,3,4, Si Hu6, Xudan Shi7, Wei Wang1, Liang Xu2,3,4* and Zixin Wang1*
1Department of Nursing, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
2Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China4State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China
5Neuroscience Intensive Care Unit, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Department of Neurosurgery, Affiliated Huzhou FuYin Hospital of Huzhou University, Huzhou, China
7Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Edited byMd. Mohaimenul Islam, The Ohio State University, United States
Reviewed byRizaldy Taslim Pinzon, Duta Wacana Christian University, IndonesiaMedha Sharath, Bangalore Medical College and Research Institute, IndiaDhrumil Shah, Super Metro Specialized Medical Center, KuwaitLuis E. Fernández-Garza, Mexican Institute of Social Security, Mexico>
*CorrespondenceLiang Xu, drliangxu@zju.edu.cn; Zixin Wang, zixinwang@zju.edu.cn
†These authors have contributed equally to this work
Received 04 February 2025Accepted 21 March 2025Published 02 April 2025
CitationXu X, Zhang G, Liu F, Zheng J, Jiang Z, Hu S, Shi X, Wang W, Xu L and Wang Z (2025) Association of neutrophil-to-lymphocyte ratio with stroke morbidity and mortality: evidence from the NHANES 1999–2020. Front. Med. 12:1570630. doi: 10.3389/fmed.2025.1570630
Background:
Stroke is closely linked to inflammation, with the neutrophil-to-lymphocyte ratio (NLR) emerging as a promising inflammatory marker. This study aims to investigate the association between NLR and both morbidity and mortality in stroke patients.
Methods:
Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2020 were analyzed, including adults with complete neutrophil and lymphocyte count records. Multivariate logistic regression was used to examine the relationship between NLR and both stroke morbidity and all-cause mortality. Restricted cubic spline regression was employed to assess potential nonlinearity in these associations. Subgroup analyses were performed to identify influencing factors.
Results:
After adjusting for confounders, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for stroke in the higher NLR quartiles, compared to the lowest quartile, were 1.28 (1.07–1.52) and 1.36 (1.12–1.65), respectively. The restricted cubic spline curve indicated a nonlinear positive association between NLR and stroke risk. Additionally, an elevated NLR was positively associated with an increased risk of all-cause mortality.
Conclusion:
The findings underscore the potential use of NLR in stratifying and predicting mortality risk in stroke patients, suggesting its relevance in clinical practice. (I'd have you all fired for useless research!)
More at link.
Xin Xu1†, Guoqiang Zhang2,3,4†, Fei Liu3,4,5†, Jingwei Zheng2,3,4, Zhijie Jiang2,3,4, Si Hu6, Xudan Shi7, Wei Wang1, Liang Xu2,3,4* and Zixin Wang1*
1Department of Nursing, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
2Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China
4State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China
5Neuroscience Intensive Care Unit, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
6Department of Neurosurgery, Affiliated Huzhou FuYin Hospital of Huzhou University, Huzhou, China
7Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Edited by
Md. Mohaimenul Islam, The Ohio State University, United States
Reviewed by
Rizaldy Taslim Pinzon, Duta Wacana Christian University, Indonesia
Medha Sharath, Bangalore Medical College and Research Institute, India
Dhrumil Shah, Super Metro Specialized Medical Center, Kuwait
Luis E. Fernández-Garza, Mexican Institute of Social Security, Mexico>
*Correspondence
Liang Xu, drliangxu@zju.edu.cn; Zixin Wang, zixinwang@zju.edu.cn
†These authors have contributed equally to this work
Background:
Received 04 February 2025
Accepted 21 March 2025
Published 02 April 2025
Citation
Xu X, Zhang G, Liu F, Zheng J, Jiang Z, Hu S, Shi X, Wang W, Xu L and Wang Z (2025) Association of neutrophil-to-lymphocyte ratio with stroke morbidity and mortality: evidence from the NHANES 1999–2020. Front. Med. 12:1570630. doi: 10.3389/fmed.2025.1570630
Stroke is closely linked to inflammation, with the neutrophil-to-lymphocyte ratio (NLR) emerging as a promising inflammatory marker. This study aims to investigate the association between NLR and both morbidity and mortality in stroke patients.
Methods:
Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2020 were analyzed, including adults with complete neutrophil and lymphocyte count records. Multivariate logistic regression was used to examine the relationship between NLR and both stroke morbidity and all-cause mortality. Restricted cubic spline regression was employed to assess potential nonlinearity in these associations. Subgroup analyses were performed to identify influencing factors.
Results:
After adjusting for confounders, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for stroke in the higher NLR quartiles, compared to the lowest quartile, were 1.28 (1.07–1.52) and 1.36 (1.12–1.65), respectively. The restricted cubic spline curve indicated a nonlinear positive association between NLR and stroke risk. Additionally, an elevated NLR was positively associated with an increased risk of all-cause mortality.
Conclusion:
The findings underscore the potential use of NLR in stratifying and predicting mortality risk in stroke patients, suggesting its relevance in clinical practice. (I'd have you all fired for useless research!)
More at link.
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