Synapse formation in parvalbumin-expressing interneurons underlies motor improvements following post-stroke rehabilitation and offers a drug target for stroke recovery, new research suggests. Task-based rehabilitation training in a mouse model of stroke selectively enhanced the synaptic input from parvalbumin interneurons to neurons that projected to the site of stroke induction, which resulted in motor recovery. Furthermore, the same outcome was achieved through pharmacological enhancement of parvalbumin interneuron function. The results demonstrate the potential of developing a rehabilitation drug for stroke — an area in which pharmacological therapies are currently lacking.
“The results demonstrate the potential of developing a rehabilitation drug for stroke”
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