Restoring brain barriers: an innovative approach for treating neurological disorders

 With your brain barrier disruption post stroke, your competent? doctor needs to follow this to fix your stroke problems. Think your doctor will do that? NO? So, you DON'T have a functioning stroke doctor, do you? And with NO stroke leadership or strategy no one will put two and two together and figure out how to fix stroke problems.

 Inflammatory action leaking through the blood brain barrier.

Lysosomal Membrane Permeabilization as a Key Player in Brain Ischemic Cell Death: a “Lysosomocentric” Hypothesis for Ischemic Brain Damage

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Restoring brain barriers: an innovative approach for treating neurological disorders

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Abstract

The complex etiology of neurological disorders is a major challenge to the identification of therapeutic candidates. Tackling brain vascular dysfunction is gaining attention from the scientific community, neurologists and pharmaceutical companies, as a novel disease-modifying strategy. Here, we provide evidence that at least 41% of neurological diseases and related conditions/injuries display a co-pathology of blood-brain and blood-spinal cord barrier alterations and dysfunctions, and we discuss why this figure may represent only a fraction of a larger phenomenon. We further provide clinical evidence that barrier status may contribute to pathological and functional outcomes in patients. Finally, we discuss drug candidates under development to repair brain barriers.