Monday, August 25, 2025

Association between constipation and risk of stroke: a systematic review and meta-analysis

 Here's a vicious circle your competent? doctor has to navigate. The best solution would be 100% recovery and getting back to your daily life, but that won't occur, your doctor has been incompetent in getting research done for 100% recovery protocols.

The incidence of constipation for stroke was 48%. 

Laxative use may be linked to dementia risk, study says

So, maybe marijuana?

Marijuana use linked with decreased constipation

You'll have to break thru your doctor's reluctance.

Luckily now a lot of states have legal marijuana sales.









 Association between constipation and risk of stroke: a systematic review and meta-analysis


Feng Tang&#x;Feng Tang1Tianjun Zhao&#x;Tianjun Zhao2Peiwen DongPeiwen Dong1Kaidi SunKaidi Sun1Xiaobin Sun
Xiaobin Sun1*Qiong Wang
Qiong Wang1*
  • 1Department of Gastroenterology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China
  • 2Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Cardiovascular Disease Research Institute of Chengdu, Chengdu, China

Objective: This systematic review and meta-analysis aimed to evaluate the association between constipation and stroke risk, with subgroup analyses exploring effects on stroke subtypes.

Methods: We systematically searched PubMed, Web of Science, and Cochrane Library until February 2025. Published studies reporting adjusted odds ratios (ORs), hazard ratios (HRs), or relative risks (RRs) for stroke in constipated versus non-constipated individuals were included. A random-effects model was used to pool effect estimates, with heterogeneity assessed via the chi-square test based on Cochrane Q statistics. Subgroup evaluations were conducted for stroke type (ischemic/hemorrhagic), region, study design, and sex.

Results: Thirteen studies involving 684,123 constipation cases and 5,223,378 controls were analyzed. Constipation was associated with a 23% increased stroke risk (pooled OR = 1.23, 95% CI: 1.10–1.36, I2 = 96.51%). Subgroup analyses revealed a stronger association with ischemic stroke (OR = 1.39, 95% CI: 1.19–1.60, I2 = 96.64%) but not hemorrhagic stroke (OR = 1.03, 95% CI: 0.80–1.26, I2 = 78.38%). Notably, constipation showed no stroke risk elevation in women (OR = 1.00, 95% CI: 0.92–1.07, I2 = 0%).

Conclusion: Our meta-analysis identified constipation as a risk factor for ischemic stroke, but not hemorrhagic stroke. These findings underscore constipation as a modifiable risk factor in ischemic stroke management, warranting further mechanistic and interventional studies.

Systematic Review Registration: PROSPERO 2024; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024615237.


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