17 pages at the link which your competent? doctor will distill into EXACT PREVENTION PROTOCOLS, right? Oh no, NOTHING HAPPENED, LIKE USUAL!
Do you prefer your doctor and hospital incompetence NOT KNOWING? OR NOT DOING?
The reason you need dementia prevention:
1. A documented 33% dementia chance post-stroke from an Australian study? May 2012.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
3. A 20% chance in this research. July 2013.
Biofilm-associated proteins: from the gut biofilms to neurodegeneration
| Authors: | Valle Turrillas, Jaione |
| Funders: | Agencia Estatal de Investigación (España) Ministerio de Ciencia e Innovación (España) |
| Keywords: | Amyloid Biofilm Biofilm-associated protein Gut microbiota α-synuclein |
| Issue Date: | Dec-2025 |
| Publisher: | Taylor & Francis |
| Citation: | Gut Microbes 17(1): 2461721 (2025) |
| Abstract: | Human microbiota form a biofilm with substantial consequences for health and disease. Numerous studies have indicated that microbial communities produce functional amyloids as part of their biofilm extracellular scaffolds. The overlooked interplay between bacterial amyloids and the host may have detrimental consequences for the host, including neurodegeneration. This work gives an overview of the biofilm-associated amyloids expressed by the gut microbiota and their potential role in neurodegeneration. It discusses the biofilm-associated proteins (BAPs) of the gut microbiota, maps the amyloidogenic domains of these proteins, and analyzes the presence of bap genes within accessory genomes linked with transposable elements. Furthermore, the evidence supporting the existence of amyloids in the gut are presented. Finally, it explores the potential interactions between BAPs and α-synuclein, extending the literature on amyloid cross-kingdom interactions. Based on these findings, this study propose that BAP amyloids act as transmissible catalysts, facilitating the misfolding, accumulation, and spread of α-synuclein aggregates. This review contributes to the understanding of complex interactions among the microbiota, transmissible elements, and host, which is crucial for developing novel therapeutic approaches to combat microbiota-related diseases and improve overall health outcomes. |
| Publisher version (URL): | https://doi.org/10.1080/19490976.2025.2461721 |
| URI: | http://hdl.handle.net/10261/396268 |
| DOI: | 10.1080/19490976.2025.2461721 |
| ISSN: | 1949-0976 |
| E-ISSN: | 1949-0984 |
| User license: | https://creativecommons.org/licenses/by/4.0/ |
| Source works: | The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1080/19490976.2025.2461721© 2025 CSIC. Published with license by Taylor & Francis Group, LLC.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the AcceptedManuscript in a repository by the author(s) or with their consent. |
| Appears in Collections: | (IDAB) Artículos |
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