Preventive Role of Cocoa-Enriched Extract Against Neuroinflammation in Mice

 Your incompetent? doctor was so bad they ignored/didn't know about all this earlier research! OVER A DECADE OF COMPLETE FUCKING INCOMPETENCE EVERYWHERE!

cocoa (20 posts to August 2012)

cocoa beans (1 post to January 2015)

Cocoa flavanols (13 posts to April 2015)

neuroinflammation (55 posts to December 2015)

Do you prefer your doctor, hospital and board of director's incompetence NOT KNOWING? OR NOT DOING?

Preventive Role of Cocoa-Enriched Extract Against Neuroinflammation in Mice

,

Olaia Martínez-Iglesias

,

Vinogran Naidoo

and

Ramón Cacabelos

EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, Spain

^*

Author to whom correspondence should be addressed.

Neurol. Int. 2025, 17(4), 47; https://doi.org/10.3390/neurolint17040047

Submission received: 12 February 2025 / Revised: 12 March 2025 / Accepted: 19 March 2025 / Published: 24 March 2025

Download keyboard_arrow_down

Browse Figures

Versions Notes

Abstract

Background: Chronic aberrant inflammation is a crucial step in mediating cerebrovascular and neurodegenerative pathologies, including Alzheimer’s and Parkinson’s disease. Due to their exceptional antioxidant properties and ability to alter imbalance metabolism and reactive inflammation response, cocoa-derived flavanols are being investigated as potential bioactive substances to modulate and reverse these inflammation-associated disorders. Objective: The present study will focus on the possible beneficial effects of cocoa-derived extract, enhanced with other bioactive phytochemicals such as spirulina and pineapple, on selected biomarkers of the inflammatory, metabolic, and neurodegenerative processes. Methods: A mice model of inflammation was treated with cocoa-derived extract cocktail, and biomolecular data was obtained by performing immunohistochemical and biochemical analysis. Results: Results show that the cocoa-derived extract mitigates the neuroinflammatory processes triggered (decreased expression of macrophage CD11b) and prevents the escalade of subsequent neurodegeneration pathologies. Conclusions: The results based on hypo-vitaminosis, neuroinflammation, and inmunoreactive analysis suggest that cocoa-derived extract is a powerful bioproduct for ameliorating neuroinflammatory processes that mediate metabolic and cerebrovascular diseases.