Therapeutic potential of myokines and myometabolites for brain ageing and neurodegeneration

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Therapeutic potential of myokines and myometabolites for brain ageing and neurodegeneration

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• Published: 08 October 2025

• Mamta Rai & 
• Fabio Demontis 

Nature Reviews Endocrinology (2025)Cite this article

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Neurodegeneration is not merely determined by local cues but is also influenced by systemic signals, such as factors released by peripheral tissues. Muscle-to-brain communication via muscle-secreted signalling factors is increasingly recognized as an important signalling axis. Collectively, muscle-to-brain signalling could be harnessed to impede neurodegeneration and delay cognitive decline during ageing.

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