Friday, March 15, 2013

Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke

Only 13 years old so you'll have to rag on your doctor and speech therapist why they haven't mentioned this to you, either good or bad.
http://link.springer.com/article/10.1007%2Fs100720070114?LI=true

Abstract

The objectives of this study were to investigate the efficacy of bromocriptine (BR) combined with speech therapy (ST) to improve a late recovery in non-fluent aphasic stroke patients. We performed a double-blind study with high dosage of BR, prescribed according to a dose-escalating protocol, comprehensive of clinical data, relatives' impression, and language evaluations. The study was divided into the following phases: t-0, inclusion; t-30, language re-test to evaluate the stability of aphasia; t-90, placebo (PL) and ST; t-150, BR and ST; t-210, BR; t-270, wash-out. With respect to the baseline assessment, a significant improvement was observed in the following tests: dictation (F, 4.8;  p < .04), reading-comprehension (F, 8.1;  p < .0003), repetition (F, 3.8; p < .01) and verbal latency (F, 4.9;  p < .01). High dosage of BR promoted a late recovery in stable chronic non-fluent aphasia and this improvement was enhanced by combination with ST.

2 comments:

  1. It sounded good until I read that 5 of the 11 people dropped out of the study due to side effects like seizures and atrial fibrilation.

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  2. Thats why we need free access to research, I'm not paying $30 for each of the dozens of reports I'd like to read each day.

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