UW Spinoff Impel Neuropharma Passes Key Nose-to-Brain Clinical Trial

Our researchers should be jumping for joy. Now we just need our Great stroke association to push some of the 177 hyperacute possibilities thru this delivery method. With that in place we could significantly reduce the disability from strokes. Ask your doctor for their ideas on how to reduce stroke damage. If none are forthcoming, ask yourself why you are seeing someone so incurious.
Delivery time in 10-20 minutes. Now if you could objectively determine that an ischemic stroke occurred you could have tPA  delivered via this method in the ambulance.
http://www.xconomy.com/seattle/2013/04/18/uw-spinoff-impel-neuropharma-passes-key-nose-to-brain-clinical-trial/
Seattle-based Impel Neuropharma has been working for five years to show it can quickly deliver drugs through the nose, directly to the brain, for the treatment of central nervous system disorders. The animal data so far has been encouraging, but now the company has got key confirmation that it can do its thing in human beings.
Impel, a University of Washington spinoff, is announcing today that it has gotten those positive results from a study of seven patients, which was supported by one of its pharmaceutical collaborators. Full details are being saved for a peer-reviewed publication, but Impel chief scientist John Hoekman says that the company’s nose-to-brain drug delivery device was able to propel a small peptide molecule deep into the upper nasal passages and to the brain stem at an “order of magnitude” greater concentration than a conventional nasal spray.
The study enrolled research subjects at the Lovelace Respiratory Research Institute in Albuquerque, NM, Hoekman says. Researchers used an off-the-shelf peptide (not an actual drug candidate), attached to a radioactive tracer molecule, and used noninvasive SPECT imaging technology to confirm that the drug was getting delivered to the brain. Volunteers in the study were able to self-administer the compound through the nose, and researchers saw it get delivered to the destination within 10 to 20 minutes, Hoekman says.

More at link.