Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, December 25, 2012

Hyperacute options for stroke

All these probably need human clinical trials. But if you really want to reduce the damage from stroke you need to have stuff like this that stops/reduces the neuronal cascade of death. This is not going to be easy as Dr. Michael Tymianski, of the Toronto Western Hospital Research Institute in Canada states;  over the last half-century, there have been more than 1,000 drugs (So what are they?)aimed at preventing brain damage that have failed to work in people, even though they worked well in mice or rats. If we had a Great stroke association they would have a listing of all these drugs and why they failed so other researchers could build off the failures. I tried contacting him but his email address returned undeliverable. Someone here knows him so ask for the list of 1000.
For some of these I'm going to ask my ER doctor to administer them to me when I have another stroke.  And damn their lack of giving me options.

I put these all in one place for those too lazy to follow the research on their own and even too lazy to read thru my whole blog.  And to make it easier to refer to all these options in one place.

This is so incredibly obvious. Have your stroke association sponsor researchers looking into these options.  Just like the Alzheimers Foundation and the Myelin Repair Foundation and the Michael J. Fox Foundation that sponsor research. These at least are for persons with those diseases. Our stroke associations seem to be for doctors with the stroke 'victims' acting as magnets for donations. My opinion in this matter is that any non-profit/charity with stroke in its name should be led by a survivor and have a survivor board of directors. Anything else just leads to complacency.
But then I'm a stroke-addled survivor who just should get out of the way of the perfect medical gods. Too bad I'm an atheist, I don't listen to gods.


1. Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice

2.Double Duty: Immune System Regulator Found to Protect Brain from Effects of Stroke

3. Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia

4. Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-κB-Mediated Inflammatory Responses

5. Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid

6. Polysaccharides from Wolfberry Antagonizes Glutamate Excitotoxicity in Rat Cortical Neurons
7. Extended therapeutic window and functional recovery after intraarterial administration of neuregulin-1 after focal ischemic stroke

8.  Halting Brain Injury - nontoxic carbon particles

9.  Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

10.  Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons
11.  Ibuprofen - Common Medicine Helps Repair Brain After Stroke, Study in Rats Suggests

12. Therapeutic time window important factor for cord blood cell transplantation after stroke

13.  Possible Anandamide and Palmitoylethanolamide involvement in human stroke

14.  Stroke Blood Test That Could Increase Use of Most Effective Treatment Five-Fold

15.   Quit Smoking: Electronic Cigarette Free Trial Kit To Reduce The Risk Of Stroke

16.  Ceria nanoparticles could lessen the damage from ischemic strokes

17.   Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

18.   Leg compressions may enhance stroke recovery
        Leg wraps raise hopes of saved lives after strokes

Whats so hard/expensive about doing this NOW? 

19.   Blood Flow In Brain Rebooted By Nanoparticles

20.   A cannabinoid type 2 receptor agonist attenuates blood–brain barrier damage and neurodegeneration in a murine model of traumatic brain injury

21.   University of Glasgow Study Demonstrates the Ability of Oxycyte® to Supply Oxygen to Critical Penumbral Tissue in Acute Ischemic Stroke

22.   Therapy Combining Exercise and Neuroprotective Agent Shows Promise for Stroke Victims

23.   Clinical Trials Start for Stroke Drug Developed by Scripps Research Institute, USC, and ZZ Biotech

24.   Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia

25.   Brain sponge: Stroke treatment may extend time to prevent brain damage

26.    New drug limits brain damage in stroke - Anakinra

27.   Molecule found that inhibits recovery from stroke - ephrin-A5

28.  New drug could treat Alzheimer's, multiple sclerosis and brain injury - MW151 and MW189

29.   Microvascular Repair: Post-Angiogenesis Vascular Dynamics

30.  Study Shows Most Commonly Mutated Gene in Cancer may have a Role in Stroke

31.   Swiss company Roche to support stroke research

32.   Potential treatment could prevent brain damage after strokes

33.   Mild Sensory Stimulation Completely Protects the Adult Rodent Cortex from Ischemic Stroke

34.  Intravenous Ancrod for Treatment of Acute Ischemic Stroke

35.  HOBOE (Head-of-Bed Optimization of Elevation) Study: association of higher angle with reduced cerebral blood flow velocity in acute ischemic stroke.
This is so damn easy to accomplish, your stroke center should have already implemented this.

36.   Chemokines in CNS injury and repair

37.   Poststroke depression

38.   K (ATP) Channel blockade instructs microglia to foster brain repair and neurogenesis after stroke

39.  Novel drug candidates offer new route to controlling inflammation

40.  Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

41.  Cellular therapy of a stroke

42.  Stroke treatment a step closer after trial


43.  Antibiotic may be new stroke treatment - minocycline

44.  Early Promise For Stroke Patients Given - levodopa

45.  UD researchers discover that JAM-A protein keeps blood clots in check

46.  Neuroscientists discover key protein responsible for controlling nerve cell protection - SUMO

47.  Experimental drug helps the brain recover from stroke -- in mice
LM22A - 3 day timeframe

48.  Cell-death agents in stroke

49.  Brain Injury Cell Death Prevention - Mechanical Tissue Resuscitation Shows Promise

50.  Nanoparticles home in on human tumors growing in mice’s brains, increase accuracy of surgical removal

51.    5 hypothermia possibilities

52.  Proteome Sciences plc : Stroke Biomarker License to Randox

53.  Local invention helps with brain trauma - bleeds

54.  New Stroke Recovery Option - MHC class-1 complex, PirB

55.  A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke

56.  Calling all pharmacologists: Stroke-recovery mechanism found, small molecule needed

57.  Honokiol Ameliorates Cerebral Infarction from Ischemia-Reperfusion Injury in Rats

58.  Nanoparticle device co. that could reduce drug-making costs gets fresh capital

59.  Clotbusters Print E-mail UAB Explores Innovative Stroke Therapies

60.  Thrombotech receives FDA IND approval for THR-18 Phase IIa clinical trial in stroke victims

61.   Inhalation of nitric oxide could help improve blood flow to ischemic brain

62.  LSUSHC research identifies new experimental drug for stroke - LAU-0901

63.  New drug could protect brain from stroke damage - PSD-95 inhibitors

64.  Old flu drug speeds brain injury recovery - amantadine

65.  A Novel Mechanism For Protecting The Adult Brain In Times Of Oxygen Deprivation Inspired By Naked Mole-Rats

66.  Promising New Compound For Treating Stroke - bind to PSD-95

67.  Melatonin ameliorates neural function by promoting endogenous neurogenesis through MT2 melatonin receptor in ischemic stroke mice.

68.   Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury in rats Laboratory investigation

69.  Hypoxia sensitive genes and respiratory neuroplasticity

70.  The Loop Diuretic Bumetanide Blocks Posttraumatic p75NTR Upregulation and Rescues Injured Neurons

71.  Thrombin Activity Associated with Neuronal Damage during Acute Stage of Ischemic Stroke

72.  Clot-Busting Drug May Work for Those Who Have Strokes While Asleep

73.  Exciting Data from Remedy Pharmaceutical-Sponsored Stroke Drug Trial to Be Presented at the 2012 International Stroke Conference - hemorrhage

74.  Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid

75.  β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

76.  Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation  - from 1996

77.   Angiogenesis at short and longer intervals post ischemia: Relationship to neuroprotective actions of resveratrol

78.  Knockdown of BNIP3 death gene family protects neurons from oxygenand- glucose-deprivation (OGD)-induced cell death

79.  Brain damage, sex hormones and recovery: a new role for progesterone and estrogen? - from 2001

80.  Search for the Brain's First Defense

81.  Bidirectional control of CNS capillary diameter by pericytes

82.  Glial growth factor 2 promotes functional recovery with treatment initiated up to 7 days after permanent focal ischemic stroke

83.  Treatment of stroke with opiate antagonists — Effects of exogenous antagonists and dynorphin 1–13 - from 1985

84.  Activating brain protein shown to aid in stroke recovery - Cutamesine

85.  Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator - from 1989

86.  Continuous theta burst stimulation over the contralesional sensory and motor cortex enhances motor learning post-stroke

87.   Discovery Of Key To Survival Of Brain Cells

88.   Identification Of Gene Critical For Cell Responses To Oxygen Deprivation May Have Implications For Heart Disease, Stroke And Cancer

89.  How Does A "Good" Protein Hurt Brain Cells After Clot-induced Stroke? - Thrombin

90.  Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent - used in Japan since 2001

91.  Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal ischemia

92.  Future of Stroke Treatment May Include Supplementation

93.  Sensory Stimulation Protects from Stroke Damage in Awake Animals - Whiskers

94.  Nano-drugs against stroke (health)

95.  Protecting The Brain When Energy Runs Low

96.  A 'First Step' Towards Perfect Drug Combinations

97.  Potential New Treatment For Stroke

98.  Researchers Report Progress On Compound To Treat Neurological Diseases

99.  Infection Is An Important Post-Stroke Problem

100.  Identification Of Gene Critical For Cell Responses To Oxygen Deprivation May Have Implications For Heart Disease, Stroke And Cancer

101.  Breaching the blood-brain barrier: Researchers may have solved 100-year-old puzzle

102.  The influence of positioning upon cerebral oxygenation after acute stroke: a pilot study

103.  Cypin protein could prevent secondary damage after stroke

104.  Stroke related -Scientists prevent cerebral palsy-like brain damage in mice - Nmnat1

105.  Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke.

106.  Pluristem's PLX Cells May Effectively Treat Ischemic Stroke - Brain Research Journal Reports - 8 and 24 hours after

107.  Protecting Nerve Cells from Death in a Model of Stroke

108.  New Insight Into How The Brain Regenerates After Stroke

109.  Sensory Stimulation Not Enough 'Good' Cholesterol Makes It Harder To Recover From Stroke

110.  Blood-pressure-lowering drug after stroke aids recovery, study finds

111.  Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth

112.  A New Therapeutic Strategy for Acute Ischemic Stroke

113.  The Albumin in Acute Stroke Part 1 Trial

114.  Brain receptors targeted for Alzheimer’s drug and Stroke

115.  Self-Assembling Peptide Nanofiber Scaffold (SAPNS) and Regeneration

116.  Progesterone for Traumatic Brain Injury Tested in Phase III Clinical Trial

117.   Nano Neurology and the Four P's of Central Nervous System Regeneration: Preserve, Permit, Promote, Plasticity

118.  New Clue to Brain Bleeding After Stroke Treatment

119.  Introducing CerAxon®, the First & Only Oral Solution Medical Food for Dietary Management of Brain Ischemia in Patients With Partially Impaired Swallow

120.  Wnt/ beta-catenin Signaling Is Active Post-stroke and Wnt-3a Liposomes Promote Neurogenesis and Functional Recovery Post-MCAO - 2,4 and 6 days post

121.  New research discovers key to survival of brain cells

122.  Study of COX-2 inhibitors could lead to new class of stroke drugs

123.  Study eyes EP4 receptors for stroke treatment

124.   Window of opportunity to treat some stroke patients may be longer than originally suspected

125.  Is Lithium a Potential Aid in Traumatic Brain Injury?

126.  Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke

127.  Restoring Capillary Blood Flow after a Stroke

128.  The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke

129.  Discovery Of A Natural Protection Mechanism In Some Nerve Cells Could Benefit Stroke Victims

130.  Omega-3 fatty acids reduce stroke severity

131.  The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma

132.  Target for Pain May Also Reduce Brain Injury from Trauma

133.   BEETS & BRAIN HEALTH

134.   STROKE: a new(12 hour) treatment through the lens of the eye

135.  Scientists discover potential stroke treatment that may extend time to prevent brain damage

136.  Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents

137.  Natural Neuroprotective Self-Repairs Brain Following Stroke

138. Nanotubes inject stroke therapy into rats’ brains

139.  Blocking Stress-Related Cell Death Could Provide New Drug Development Target For Heart Attack, Stroke And Parkinson's 

140. New Understanding Of Brain Chemistry Could Prevent Brain Damage After Injury

141.  Cholesterol-lowering drugs may help clot-busting drugs treat strokes
This one had been tested in rats 5 years prior to my stroke and if anyone had been checking the research they could have asked me if I wanted to take statins because in rats it helped. I would have said yes. But I bet even now this is not standard. You can't check because the Joint Commission hides stuff. 

142.  Simple Injection Could Limit Damage From Heart Attacks And Stroke

143.  Survival protein’ protects the brain against effects of stroke 

144.  Draculin, Stroke Drug From Vampire Bats, Moves Closer to Circulation 

145.  snake venom and stroke rehab

146.  Apoptosis: a target for neuroprotection

 147.  iron deposition and acute stroke rehab

148.  Ablation in Ischemic Stroke

149. nicotine and stroke rehab part 2 

150. exosomes delivering drugs to brain 

151.  music listening and stroke rehab 
This seems like such a no-brainer, low cost, no side effects unless you are like Jill Bolte-Taylor.

152. The Science of Stroke: Mechanisms in Search of Treatments Dr. Michael A. Moskowitz

153.  New Zealand stroke research

154.   A Nasal Spray against Alzheimer's Disease and Stroke 

155.    xenon gas and stroke rehab

156.    bubbles with ultrasound - stroke drugs directly into the brain
Is it the bubbles or the xenon gas?

157.  tumeric and stroke rehab 

158.  'Irish coffee' injection prevents stroke damage
caffeinol - from 2003, so what happened to it?

159.  Sigma-1 receptor and stroke rehab 

160.  Marijuana and stroke rehab 

161.  Protecting the Brain from a Glutamate Storm

162.   nanoparticles and stroke rehab

163. The neuroprotective actions of hypoxic preconditioning and postconditioning in a neonatal rat model of hypoxic ischemic brain injury

164. MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

165. Cannabinoid Trans-Caryophyllene Protects Brain Cells From Ischemia

166. Small Quantities Of Marijuana Protect Against Brain Damage

167. Amelioration of ischemic brain damage by peritoneal dialysis

168. Intravenous Minocycline in Acute Stroke

169. Mouth implant to save stroke victims from brain damage 

170. Reducing fever after a stroke with acetoaminophen

171. A COMBINATION THERAPY OF NICOTINAMIDE AND PROGESTERONE FOR FUNCTIONAL RECOVERY FOLLOWING TRAUMATIC BRAIN INJURY

172. Histone H1 - A New Player In Brain Disease And Stroke

173. Ebselen stroke

174. Can Caresses Protect the Brain from Stroke? from Scientific American

175. Cranberries could reduce stroke damage

176. Research Shows Tocomin® May Improve Stroke Outcome - alpha-tocotrienol

177. Lipoprotein Receptor–Related Protein-6 Protects the Brain From Ischemic Injury















 
 
 

1 comment:

  1. A feisty, in-your-face, not at all wrong, rant! Good work, Dean!

    ReplyDelete