Tuesday, May 7, 2013

Neuroglobin expression in neurogenesis

Have your doctor translate this into a stroke protocol. Tell him/her you want neurogenesis to occur in your brain and you expect them to have answers in how to do it.
Isn't that what your neurologist is for?
http://www.sciencedirect.com/science/article/pii/S0304394013003984

Abstract

Neuroglobin is a hypoxia-inducible, neuroprotective protein related to myoglobin and hemoglobin, but little is known about its neurodevelopmental expression or function. To begin to explore these issues, we measured neuroglobin protein expression during neuronal differentiation of human embryonic stem cells in vitro and in the neurogenic subventricular zone of adult rats in vivo. Neuroglobin protein expression was barely detectable by western blotting in human embryonic stem cells, but was readily demonstrable in neural stem cells, and was further induced upon differentiation to neurons. In the adult subventricular zone, neuroglobin expression coincided with that of the neuronal lineage marker doublecortin, but not with vimentin or glial fibrillary acidic protein. These findings suggest that neuroglobin is expressed early in the course of neuronal differentiation and may, therefore, have a role in neurodevelopment.

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