Tuesday, July 2, 2013

Exercise facilitates the action of dietary DHA on functional recovery after brain trauma

Is your doctor going to realize the significance of the highlighted lines. Fish oil is going to be one of my demands immediately after my stroke. I know it says TBI but I'll take the chance it works for stroke.  What the downside? Fish breath?
http://www.sciencedirect.com/science/article/pii/S0306452213005472

Highlights

Exercise facilitates the action of DHA in preserving DHA homeostasis after TBI.
Exercise enhances the effects of DHA on counteracting the outcome of TBI.
These findings may have important therapeutic potential for the treatment of TBI.

Abstract

The abilities of docosahexaenoic acid (DHA) and exercise to counteract cognitive decay after TBI is getting increasing recognition; however, the possibility that these actions can be complementary remains just as an intriguing possibility. Here we have examined the likelihood that the combination of diet and exercise has the added potential to facilitate functional recovery following TBI. Rats received mild fluid percussion injury (mFPI) or sham injury and then were maintained on a diet high in DHA (1.2% DHA) with or without voluntary exercise for 12 days. 

We found that FPI reduced DHA content in the brain, which was accompanied by increased levels of lipid peroxidation assessed using 4-HHE. FPI reduced the enzymes Acox1 and 17β-HSD4, and the calcium-independent phospholipases A2 (iPLA2), which are involved in metabolism of membrane phospholipids. FPI reduced levels of syntaxin-3 (STX-3), involved in the action of membrane DHA on synaptic membrane expansion, and also reduced BDNF signaling through its TrkB receptor. 

These effects of FPI were optimally counteracted by the combination of DHA and exercise. Our results support the possibility that the complementary action of exercise is exerted on restoring membrane homeostasis after TBI, which is necessary for supporting synaptic plasticity and cognition. It is our contention that strategies that take advantage of the combined applications of diet and exercise may have additional effects to the injured brain.

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