Aminopropyl Carbazole Analogues as Potent Enhancers of Neurogenesis

I want to know when someone is going to create a stroke protocol from this.
http://www.sciencedirect.com/science/article/pii/S0968089613007694

• Hye Jin Yoon^{a, 1},
• Sun-Young Kong^{b, 1},
• Min-Hye Park^b,
• Yongsung Cho^a,
• Sung-Eun Kim^a,
• Jae Yeon Shin^b,
• Sung Hye Jung^b,
• Jiyoun Lee^c,
• Farhanullah^d,
• Hyun-Jung Kim^{b, 2,} ,
• Jeewoo Lee^{a, ,}

• ^a Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
• ^b Laboratory of Molecular and Stem Cell Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea
• ^c Department of Global Medical Science, Sungshin Women’s University, Seoul 142-732, Korea
• ^d Medicinal Chemistry Division, GVK Biosciences Pvt Ltd, Hyderabad 500076, India

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Abstract

Neural stem cells are multipotent and self-renewing cells that can differentiate into new neurons and hold great promise for treating various neurological disorders including multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. Small molecules that can trigger neurogenesis and neuroprotection are particularly useful not only because of their therapeutic implications but also because they can provide an invaluable tool to study the mechanisms of neurogenesis. In this report, we have developed and screened 25 aminopropyl carbazole derivatives that can enhance neurogenesis of cultured neural stem cells. Among these analogues, compound 9 demonstrated an excellent proneurogenic and neuroprotective activity with no apparent toxicity. We believe that compound 9 can serve as an excellent lead to develop various analogues and to study the underlying mechanisms of neurogenesis.