Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells and protects hypoxia-induced decrease in hippocampal neurogenesis

You'll have to ask your doctor what protocol they are going to create for this. Is it administered into the blood, digested or do you have to breathe the stinky gas?
http://www.sciencedirect.com/science/article/pii/S0091305713003018

• Dexiang Liu^{a, b},
• Zhen Wang^{b, c},
• Jingmin Zhan^b,
• Qun Zhang^c,
• Jianmei Wang^c,
• Qingrui Zhang^b,
• Xiuying Xian^b,
• Qinsong Luan^c,
• Aijun Hao^{b, ,}

• ^a Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China
• ^b Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong Provincial Key Laboratory of Mental Disorders, Department of Histology and Embryology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China
• ^c Institute of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China

Choose an option to locate/access this article:

Check if you have access through your login credentials or your institution

Check access

Purchase $27.95

• 

---

Highlights

•

Hydrogen sulfide promotes proliferation of neural stem cells.

•

Hydrogen sulfide promotes neuronal differentiation of neural stem cells.

•

Hydrogen sulfide protects hypoxia-induced decrease in hippocampal neurogenesis.

---

Abstract

Accumulating evidence has suggested that hydrogen sulfide (H₂S) acts as a novel neuro-modulator and neuroprotective agent; however, it remains to be investigated whether H₂S has a direct effect on neural stem cells (NSCs). In the present study, we examined the effects of H₂S donor, sodium hydrosulfide (NaHS) on mouse NSCs and hippocampal neurogenesis. We report here that NaHS promoted proliferation and neuronal differentiation of NSCs. Further analysis revealed that NaHS-induced proliferation was associated with phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and neuronal differentiation was linked to altered expression of differentiation-related genes. In addition, C57BL/6 mice (1 day old) subjected to hypoxia were treated with NaHS to explore whether H₂S would influence the neurogenesis of hippocampus. BrdU incorporation assay results showed that administration of NaHS could increase the number of proliferating cells in the dentate gyrus of hippocampus in the mice after hypoxia. Moreover, Morris water maze test showed that treatment with NaHS improved cognitive impairment after hypoxia in mice. These findings suggest that H₂S may afford a novel therapeutic strategy to intervene in the progression of brain diseases.