http://www.healio.com/cardiology/arrhythmia-disorders/news/online/%7Bda4bc62f-ffd8-42cc-92a6-ff08e7867402%7D/gi-bleeding-risk-higher-with-novel-anticoagulants-than-warfarin-in-older-patients?
Gastrointestinal bleeding risk is similar for
patients assigned novel oral anticoagulants and warfarin, but clinicians
should use caution when prescribing the new agents to those older than
75 years, according to research published in The BMJ.
“By using the real-world, national data
available from the Optum Labs Data Warehouse, we were able to determine
that individuals over age 75 have a much higher risk of GI bleeds than
younger patients, if using dabigatran or rivaroxaban instead of warfarin,” Neena S. Abraham, MD,
of the Mayo Clinic, Scottsdale, Arizona, said in a news release. “Our
findings definitely point toward important age-related risk that merits
consideration when doctors are making treatment recommendations.”
Abraham and colleagues retrospectively
identified 92,816 patients with and without atrial fibrillation through
the database of administrative claims who initiated anticoagulation
therapy during a 3-year period; 8,578 (9.2%) were assigned dabigatran
(Pradaxa, Boehringer Ingelheim), 16,253 (17.5%) rivaroxaban (Xarelto,
Janssen Pharmaceuticals) and 67,985 (73.2%) warfarin.
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