http://www.trialsjournal.com/content/16/1/435
Methods
- Sixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo–opercular network, motor primary cortex and sham stimulation.
- Each group will receive transcranial direct current stimulation at an intensity of 2 mA for 20 minutes daily for 10 consecutive days.
- Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go–no go tests, Wechsler Adult Intelligence Scale, Rey Auditory–Verbal Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline and after their tenth stimulation session.
- Those who achieve clinical improvement with neurostimulation will be invited to receive treatment for 12 months as part of a follow–up study.
1
Cognitive Neuroscience and Behavior Program, Department of Psychology,
Federal University of Paraíba, João Pessoa, Brazil
2 Cognitive Neuroscience Laboratory and Developmental Disorders Program, Mackenzie Presbyterian University, São Paulo, SP, Brazil
3 Center for Research in Human Movement Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil
4 Perception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil
5 Department of Sciences of Religions, NOUS Group, Federal University of Paraíbas, João Pessoa, PB, Brazil
2 Cognitive Neuroscience Laboratory and Developmental Disorders Program, Mackenzie Presbyterian University, São Paulo, SP, Brazil
3 Center for Research in Human Movement Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil
4 Perception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil
5 Department of Sciences of Religions, NOUS Group, Federal University of Paraíbas, João Pessoa, PB, Brazil
Trials 2015, 16:435
doi:10.1186/s13063-015-0945-1
The electronic version of this article is the complete one and can be found online at: http://www.trialsjournal.com/content/16/1/435
The electronic version of this article is the complete one and can be found online at: http://www.trialsjournal.com/content/16/1/435
| Received: | 26 January 2015 |
| Accepted: | 7 September 2015 |
| Published: | 29 September 2015 |
© 2015 Andrade et al.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Abstract
Background
Stroke patients may present severe cognitive impairments, primarily related to executive
functions. Transcranial direct current stimulation has shown promising results, with
neuromodulatory and neuroplastic effects. This study is a double-blind, sham-controlled
clinical trial aiming to compare the long-term effects of stimulation in two different
cognitive regions after a stroke.
Methods/Design
Sixty patients who suffer from chronic strokes will be randomized into one of four
groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex
and sham stimulation. Each group will receive transcranial direct current stimulation
at an intensity of 2 mA for 20 minutes daily for 10 consecutive days. Patients will
be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical
verbal fluency and Go-no go tests, Wechsler Adult Intelligence Scale, Rey Auditory-Verbal
Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline and after
their tenth stimulation session. Those who achieve clinical improvement with neurostimulation
will be invited to receive treatment for 12 months as part of a follow-up study.
Discussion
Long-term stimulation could be analyzed in regard to possible adaptive changes on
plasticity after structural brain damage and if these changes are different in terms
of clinical improvement when applied to two important cognitive centers.
Trials registration
Clinicaltrials.gov, NCT02315807. 9 December 2014.
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