Wednesday, November 11, 2015

Feasibility of progesterone treatment for ischaemic stroke

Since I have no idea what the failed trials looked like I can't tell if they were run properly or came to the right conclusions. Our fucking failures of stroke associations should know this  and be following up with research for stroke.
http://jcb.sagepub.com/content/early/2015/11/10/0271678X15616782.abstract?&
  1. Claire L Gibson1
  2. Philip M Bath2
  1. 1Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK
  2. 2Stroke, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK
  1. Claire L Gibson, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 9HN, UK. Email: cg95@le.ac.uk

Abstract

Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts on the translational potential of progesterone treatment for ischaemic stroke. A wealth of experimental evidence supports the neuroprotective properties of progesterone, and associated metabolites, following various types of central nervous system injury. In particular, for ischaemic stroke, studies have also begun to reveal possible mechanisms of such neuroprotection. However, the results in traumatic brain injury now question whether further clinical development of progesterone for ischaemic stroke is relevant.

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