Monday, November 23, 2015

Mechanisms and Functional Significance of Stroke-induced Neurogenesis

If I had a 'good' stroke doctor I would expect that person to have read this and updated stroke protocols within a week. Then contacting every single stroke patient of theirs to inform them of the good news. But I bet there isn't one single 'good' stroke doctor in the world. Not even great, just 'good'.  Doing that is the minimum I would expect from my doctor,. anything else should be a fireable offense.
http://journal.frontiersin.org/article/10.3389/fnins.2015.00458/abstract

  • 1GIGA-Neurosciences, University of liège, Belgium
Stroke affects one in every six people worldwide, and is the leading cause of adult disability. After stroke, some limited spontaneous recovery occurs, the mechanisms of which remain largely unknown. Multiple, parallel approaches are being investigated to develop neuroprotective, reparative and regenerative strategies for the treatment of stroke. For years, clinical studies have tried to use exogenous cell therapy as a means of brain repair, with varying success. Since the rediscovery of adult neurogenesis and the identification of adult neural stem cells in the late nineties, one promising field of investigation is focused upon triggering and stimulating this self-repair system to replace the neurons lost following brain injury. For instance, it is has been demonstrated that the adult brain has the capacity to produce large numbers of new neurons in response to stroke. The purpose of this review is to provide an updated overview of stroke-induced adult neurogenesis, from a cellular and molecular perspective, to its impact on brain repair and functional recovery.

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