Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus After Ischemic Stroke

I have never been able to find any research proof that myelin is damaged in stroke but this research remarks on repairing myelin damage. So ask your doctor what stroke protocol is being used to repair your myelin.  You are on your own trying to translate the amount of exercise from gerbils to yourself, so get cracking on those calculations. Something our fucking failures of stroke associations should be doing but aren't. I bet there will be no followup in humans.
Maybe this:

Brain Equation: Subtract Protein, Generate Myelin-making Cells

Or maybe you need to look at the Myelin Repair Foundation

 

 

Long-Term Exercise Improves Memory Deficits via Restoration of Myelin and Microvessel Damage, and Enhancement of Neurogenesis in the Aged Gerbil Hippocampus After Ischemic Stroke

1. Ji Hyeon Ahn, PhD1
2. Jung Hoon Choi, DVM, PhD2
3. Joon Ha Park, PhD2
4. In Hye Kim, PhD2
5. Jeong-Hwi Cho, MS2
6. Jae-Chul Lee, PhD2
7. Hyun-Mo Koo, PhD3
8. Gak Hwangbo, PhD4
9. Ki-Yeon Yoo, PhD5
10. Choong Hyun Lee, DVM, PhD6
11. In Koo Hwang, DVM, PhD7
12. Jun Hwi Cho, MD, PhD2
13. Soo Young Choi, PhD1
14. Young-Guen Kwon, PhD8
15. Young-Myeong Kim, PhD2
16. Il-Jun Kang, PhD1
17. Moo-Ho Won, DVM, PhD2⇑

1. ¹Hallym University, Chuncheon, South Korea
2. ²Kangwon National University, Chuncheon, South Korea
3. ³Kyungsung University, Busan, South Korea
4. ⁴Daegu University, Gyeongsan, South Korea
5. ⁵Gangneung-Wonju National University, Gangneung, South Korea
6. ⁶Dankook University, Cheonan, South Korea
7. ⁷Seoul National University, Seoul, South Korea
8. ⁸Yonsei University, Seoul, South Korea

1. Moo-Ho Won, DVM, PhD, Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea. Email: mhwon@kangwon.ac.kr
2. Il-Jun Kang, PhD, Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, South Korea. Email: ijkang@hallym.ac.kr

Abstract

Background. The positive correlation between therapeutic exercise and memory recovery in cases of ischemia has been extensively studied; however, long-term exercise begun after ischemic neuronal death as a chronic neurorestorative strategy has not yet been thoroughly examined.  

The purpose of this study is to investigate possible mechanisms by which exercise ameliorates ischemia-induced memory impairment in the aged gerbil hippocampus after transient cerebral ischemia. 

Methods. Treadmill exercise was begun 5 days after ischemia-reperfusion (I-R) and lasted for 1 or 4 weeks. The animals were sacrificed 31 days after the induction of ischemia. Changes in short-term memory, as well as the hippocampal expression of markers of cell proliferation, neuroblast differentiation, neurogenesis, myelin and microvessel repair, and growth factors were examined by immunohistochemistry and/or western blots.  

Results. Four weeks of exercise facilitated memory recovery despite neuronal damage in the stratum pyramidale (SP) of the hippocampal CA1 region and in the polymorphic layer (PoL) of the dentate gyrus (DG) after I-R. Long-term exercise enhanced cell proliferation and neuroblast differentiation in a time-dependent manner, and newly generated mature cells were found in the granule cell layer of the DG, but not in the SP of the CA1 region or in the PoL of the DG. In addition, long-term exercise ameliorated ischemia-induced damage of myelin and microvessels, which was correlated with increased BDNF expression in the CA1 region and the DG.  

Conclusions. These results suggest that long-term treadmill exercise after I-R can restore memory function through replacement of multiple damaged structures in the ischemic aged hippocampus.