Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats

Not to be done on your own until research has created protocols in at least 50 years, because we have NO stroke leaders or strategy.
http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12700/full

• Accepted manuscript online: 7 November 2016Full publication history
• DOI: 10.1111/bcpt.12700View/save citation
• Cited by: 0 articles

• 
  

• This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/bcpt.12700
  

Abstract

The effects of acute administration of lauric acid (LA), the most abundant medium chain fatty acid of coconut oil, on blood pressure, heart rate and oxidative stress were investigated in spontaneously hypertensive rats (SHR). Intravenous doses of LA reduced blood pressure in a dose-dependent fashion (1, 3, 4, 8 and 10 mg/kg) in both SHR and Wistar Kyoto rats. LA (10^-8 to 3 x 10^-3 M) induced vasorelaxation in isolated superior mesenteric artery rings of SHR in the presence (n = 7) or absence (n = 8) of functional endothelium [maximum effect (ME) = 104 ± 3 versus 103 ± 4 %]. After exposure to KCl (60 mM), LA also induced concentration-dependent vasorelaxation (n = 7) compared to that under Phe-induced contraction (ME = 113.5 + 5.1 versus 104.5 + 4.0 %). Furthermore, LA induced vasorelaxation in vessels contracted with S(−)-BayK8644 (200 nM), a L-type Ca²⁺ channel agonist (ME = 91.4 + 4.3 versus 104.5 + 4.0 %, n = 7). Lastly, LA (10^-3 M) reduced NADPH-dependent superoxide accumulation in the heart (18 ± 1 versus 25 ± 1 MLU/min/μg protein, n = 4, P < 0.05) and kidney (82 ± 3 versus 99 ± 4 MLU/min/μg protein, n = 4, P < 0.05). Our data show that LA reduces blood pressure in normotensive and hypertensive rats. In SHR, this effect might involve Ca⁺² channels in the resistance vessels and by its capability of reducing oxidative stress in heart and kidneys.