Something that our fucking failures of stroke associations will never look at to see if any of these might change the stroke strategy of getting every stroke survivor to 100% recovery. NOTHING LESS YOU FUCKING LAZY BASTARDS.
If I was in charge every clinical trial in stroke would be part of the defined and published stroke strategy of 100% recovery for all survivors. Anything less is pure laziness. You can determine how lazy your stroke medical professionals and hospitals are by how little they talk about getting you fully recovered.
http://www.medscape.com/viewarticle/871737?nlid=110615_3005&
Results of nearly half of all clinical trials conducted in the last
decade by big drug companies have not been published, according to an
analysis of data from TrialsTracker,
an online tool that identifies trials from ClinicalTrials.gov that
haven’t published results 2 years after the end of the trial.
TrialsTracker
was developed by the AllTrials consortium, a group calling for the
results of all clinical trials to be published. The tool includes
sponsors with more than 30 interventional trials and excludes phase 1
trials.
According to the analysis, since January 2006, trial
sponsors completed 25,927 eligible trials and haven't published results
for 11,714 trials, or 45.2%. These 11,714 trials with missing results
enrolled an estimated 8.7 million patients.
"We should all be
outraged" by this, Síle Lane, director of campaigns at Sense about
Science, which runs the AllTrials campaign, said in a news release.
"Everyone
has been talking about this problem for far too long. We hope that
increasing accountability will help to drive change forward. The
TrialsTracker helps to identify the individual universities and
companies with the most overdue trials," added Ben Goldacre, MBBS,
MRCPsych, one of the founders of the AllTrials campaign for clinical
trial transparency and one of the researchers behind the TrialsTracker.
Dr Goldacre, and coauthor Anna Powell-Smith, with the Evidence-Based Medicine Data Lab, University of Oxford, United Kingdom, reported their analysis of TrialsTracker data online November 3 in F1000Research.
Drug Companies Dispute Findings
The
analysis found that Sanofi had the largest number of missing trial
results — 285 missing results from 435 eligible trials (65.5%).
But Ameet Nathwani, MD, chief of medical affairs for Sanofi, told Medscape Medical News
the company "disagrees with the AllTrials analysis, which does not
capture many of our publicly available clinical trial results. In fact,
of the 285 study results deemed missing by AllTrials, Sanofi has made
publicly available results for 255 (90%) of these studies on either the EU Clinical Trials Register or the Sanofi website.
This means that, in total, Sanofi has made publicly available the
results for 93% of the 435 studies identified by AllTrials, making us
one of the most transparent clinical trial sponsors in the world.
"We
respect and follow all relevant governmental regulations concerning the
disclosure of clinical trial results," Dr Nathwani added.
The analysis also found that Novartis did not disclose data for 201 of 534 eligible studies (37.6%).
In a statement emailed to Medscape Medical News,
Novartis said: "We are aware of the TrialsTracker initiative and are
reviewing against our own records. Initial analysis suggests the data
presented is misleading as it focuses on PubMed and clinicaltrials.gov
records, but doesn’t include other publication outlets including our own
clinical trials results website (www.novartisclinicaltrials.com)."
"Novartis
is committed to clinical data transparency and has been registering
clinical trials on clinicaltrials.gov since 1999. In May 2005, Novartis
became one of the first companies to publish interventional clinical
trial results within one year of trial completion, regardless of
outcome, on a public website. This pre-dates any country regulatory
requirement to make trial results public," the company said.
GlaxoSmithKline
didn't publish findings for 183 of 809 eligible trials (22.6%), the
analysis found. And India-based Ranbaxy Laboratories Ltd (now part of
Sun Pharma) hasn't published any results for any of the 35 trials it has
conducted in the last 10 years. GlaxoSmithKline and Sun Pharma did not
respond to a request for comment by press time.
The analysis also
found that some drug companies have done a good job of publishing
results, with Shire Pharmaceuticals leading the pack, having published
results for all of the 96 trials it has run in the last 10 years.
The other top trial sponsors with the lowest number of missing results are reported by the initiative at the F1000Research site.
The
TrialsTracker is automatically updated when new information is added to
the clinical trial register ClinicalTrials.gov. The information in the
analysis is current up to November 2, 2016.
F1000Research. Published online November 3, 2016. Full text
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