Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s Disease Phenotype

Useless piece of shit research. No amounts to take or timeframe. Followup will be required which will NEVER OCCUR. 

Our fucking failures of stroke associations will DO NOTHING. Your doctor will DO NOTHING. Your stroke hospital will DO NOTHING.  You're screwed. 

And why are they doing NOTHING? Laziness? Incompetence? Or just don't care? No leadership? No strategy? Not my job?

Oops, I'm calling into question the capability of the stroke medical world. Bad, bad Dean.

I'm not playing by the polite rules of Dale Carnegie, 'How to Win Friends and Influence People'. 
Politeness will never solve anything in stroke.

This one line in the full text is appalling;

Therefore, due to the lack of translation of experimental neuroprotective agents for use in clinical conditions [41], we have focused our attention on improving functional outcomes after ischemia, instead of protecting neurons during ischemic damage.

Meaning they have given up on stopping the 5 causes of the neuronal cascade of death in the first week. LAZY BASTARDS, LEADERS TACKLE DIFFICULT PROBLEMS THEY DON'T FUCKING RUN AWAY. I SUGGEST COURT MARTIAL WITH THE REQUISITE PUNISHMENT, THAT MIGHT CONCENTRATE THE MIND. Shouting is required, the stroke medical world must be deaf to listening to survivors. It must be the only reason I have not been contacted by any stroke doctor or hospital. They can't be afraid of poor stroke-addled me.

 

 

Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s Disease Phenotype

Ryszard Pluta ^1,* , Marzena Ułamek-Kozioł ^1,2 and Stanisław J. Czuczwar ³

¹

Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland

²

First Department of Neurology, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland

³

Department of Pathophysiology, Medical University of Lublin, 20-090 Lublin, Poland

^*

Author to whom correspondence should be addressed.

Received: 16 November 2018 / Revised: 4 December 2018 / Accepted: 10 December 2018 / Published: 12 December 2018

(This article belongs to the Special Issue Curcumin in Health and Disease)

Full-Text   |   PDF [278 KB, uploaded 12 December 2018]

Abstract

In recent years, ongoing interest in ischemic brain injury research has provided data showing that ischemic episodes are involved in the development of Alzheimer’s disease-like neuropathology. Brain ischemia is the second naturally occurring neuropathology, such as Alzheimer’s disease, which causes the death of neurons in the CA1 region of the hippocampus. In addition, brain ischemia was considered the most effective predictor of the development of full-blown dementia of Alzheimer’s disease phenotype with a debilitating effect on the patient. Recent knowledge on the activation of Alzheimer’s disease-related genes and proteins—e.g., amyloid protein precursor and tau protein—as well as brain ischemia and Alzheimer’s disease neuropathology indicate that similar processes contribute to neuronal death and disintegration of brain tissue in both disorders. Although brain ischemia is one of the main causes of death in the world, there is no effective therapy to improve the structural and functional outcomes of this disorder. In this review, we consider the promising role of the protective action of curcumin after ischemic brain injury. Studies of the pharmacological properties of curcumin after brain ischemia have shown that curcumin has several therapeutic properties that include anti-excitotoxic, anti-oxidant, anti-apoptotic, anti-hyperhomocysteinemia and anti-inflammatory effects, mitochondrial protection, as well as increasing neuronal lifespan and promoting neurogenesis. In addition, curcumin also exerts anti-amyloidogenic effects and affects the brain’s tau protein. These results suggest that curcumin may be able to serve as a potential preventive and therapeutic agent in neurodegenerative brain disorders. View Full-Text

Keywords: brain ischemia; curcumin; Alzheimer’s disease; neurodegeneration; amyloid; tau protein; autophagy; mitophagy; apoptosis; genes

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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MDPI and ACS Style

Pluta, R.; Ułamek-Kozioł, M.; Czuczwar, S.J. Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s Disease Phenotype. Int. J. Mol. Sci. 2018, 19, 4002.