Abstract
Background and Purpose—
The
purpose of this study was to investigate the association between
adiposity using adipose tissue imaging and stroke outcomes in acute
ischemic stroke patients treated with intravenous thrombolysis.
Methods—
A
total of 127 patients with acute ischemic stroke treated with
intravenous thrombolysis who underwent abdominal computed tomography on
admission were enrolled in this prospective cohort study. Patients were
grouped according to their visceral adipose tissue (VAT) proportion
tertile. The primary outcome was measured using the modified Rankin
scale 3 months after symptom onset. Favorable and excellent outcomes
were defined as modified Rankin scale scores of 0 to 2 and 0 to 1,
respectively.
Results—
As
VAT proportion tertile increased, the number of patients exhibiting a
favorable or excellent outcome decreased. In the final multivariable
analysis after adjustments for confounders, patients in the highest VAT
proportion tertile showed a decreased probability of a favorable and
excellent outcome compared with those in the lowest tertile (odds
ratio=0.18; 95% CI, 0.05−0.60; P=0.005 and odds ratio=0.13; 95% CI, 0.02−0.64; P=0.012,
respectively). Obese patients (body mass index ≥25) also showed an
excellent outcome compared with nonobese patients (odds ratio=4.88; 95%
CI, 1.47−7.85; P=0.011). Among obese patients, those with an
excellent outcome presented a significantly lower VAT proportion than
those without (38.2% versus 46.1%, P=0.006).
Conclusions—
Results
of this study indicate that low visceral abdominal fat proportion is
associated with a favorable and excellent outcome in acute ischemic
stroke patients treated with intravenous thrombolysis. Better clinical
outcomes in obese patients were also associated with a lower proportion
of VAT.
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