Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity

But what EXACTLY is the best way to get better blood flow? And wouldn't you immediately want better blood flow to your brain to try to save some of the neurons in the penumbra?

So ask your doctor for EXACT PROTOCOLS to increase blood flow.  These 72 posts contain my writings and ideas on increasing blood flow.  DO NOT FOLLOW THEM, I'M NOT MEDICALLY TRAINED. Your doctor supposedly is, so ask him/her. 

• blood flow (72 posts)

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Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity

Sakakibara S¹, Murakami R, Takahashi M, Fushimi T, Murohara T, Kishi M, Kajimoto Y, Kitakaze M, Kaga T.

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Abstract

This study examined the effect of acetate on endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) by immunoblotting assay and the ability of acetic acid to upregulate flow-mediated vasodilatation in humans. In HUVECs, acetate induced a biphasic increase in the phosphorylated form of eNOS. The amount of phosphorylated eNOS was significantly increased by exposure to 200 mumol/l acetate for 20 min (early phase) and for 4 h (late phase). The inhibitors of cAMP-dependent protein kinase (PKA) and AMP-activated protein kinase (AMPK) blocked acetate-induced eNOS phosphorylation in the early and the late phase respectively. Furthermore, in postmenopausal women, maximum forearm blood flow (FBF) in response to shear stress increased in the vinegar (acetic acid) administered group compared to the placebo group. These results suggest that acetic acid-induced eNOS phosphorylation contributes to upregulation of flow-mediated vasodilatation in humans.

PMID:

20460711

DOI:

10.1271/bbb.90953

[Indexed for MEDLINE]

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