Saturday, December 28, 2019

End-of-Treatment Intracerebral and Ventricular Hemorrhage Volume Predicts Outcome

What the hell are YOU doing to change the status quo of poor outcomes?  I hate these lazy people that inform us of not getting to 100% recovery by basically throwing up their hands in defeat and saying; 'We have nothing for that problem.'  Hope you are OK with such a fuckingly stupid answer when you are

the 1 in 4 per WHO that has a stroke and your doctor uses that line on you.

End-of-Treatment Intracerebral and Ventricular Hemorrhage Volume Predicts Outcome


A Secondary Analysis of MISTIE III
Originally publishedhttps://doi.org/10.1161/STROKEAHA.119.028199Stroke. ;0:STROKEAHA.119.028199

Background and Purpose—

Trials have shown potential clinical benefit for minimally invasive clot evacuation of intracerebral hemorrhage (ICH). Prior research showing an association between ICH size and functional outcome did not fully address the spectrum of hematoma volumes seen after clot evacuation.

Methods—

In this secondary analysis of the MISTIE III trial (Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation III), we included patients randomized to the surgical arm. The primary outcome was good outcome (modified Rankin Scale score 0–3 at 1 year from study enrollment). The primary predictors were the end-of-treatment (EoT) ICH and intraventricular hemorrhage volumes and an end-of-treatment ICH stratification scale called the EoT ICH volume score.

Results—

In 246 patients, the end-of-treatment computed tomography was performed an average of 5 days from onset. For patients with good versus poor outcomes, the mean end-of-treatment ICH and intraventricular hemorrhage volumes were 12.9 versus 18.0 mL (P=0.002) and 0.5 versus 2.3 mL (P<0.001), respectively. The probability of a good outcome decreased from 73% for EoT ICH volume 3 (<5 mL) to 28% for EoT ICH volume 0 (>20 mL; P=0.001).

Conclusion

s—After surgical clot evacuation, both ICH and intraventricular hemorrhage volumes have a strong association with good neurological outcome. The EoT ICH volume score needs independent verification, but such an approach could be used for prognostication and therapeutic planning.

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