Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,372 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Sunday, December 22, 2019
Translingual Neurostimulation for the Treatment of Chronic Symptoms Due to Mild-to-Moderate Traumatic Brain Injury
Does your doctor and stroke hospital have enough brains to use this for stroke before actual stroke trials never occur?
Or will your doctor and stroke hospital DO NOTHING since everyone in stroke is
Presented
at the International Brain Injury Association, March 13-15, 2019,
Toronto, Ontario, Canada, and American Physical Therapy Association,
January 23-29, 2019, Washington, DC.
To
compare the efficacy of high- and low-frequency noninvasive
translingual neurostimulation (TLNS) plus targeted physical therapy (PT)
for treating chronic balance and gait deficits due to mild-to-moderate
traumatic brain injury (mmTBI).
Design
Participants
were randomized 1:1 in a 26-week double-blind phase 1/2 study
(NCT02158494) with 3 consecutive treatment stages: in-clinic, at-home,
and no treatment. Arms were high-frequency pulse (HFP) and low-frequency
pulse (LFP) TLNS.
Setting
TLNS plus PT training was initiated in-clinic and then continued at home.
Participants
Participants
(N=44; 18-65y) from across the United States were randomized into the
HFP and LFP (each plus PT) arms. Forty-three participants (28 women, 15
men) completed at least 1 stage of the study. Enrollment requirements
included an mmTBI ≥1 year prior to screening, balance disorder due to
mmTBI, a plateau in recovery with current PT, and a Sensory Organization
Test (SOT) score ≥16 points below normal.
Interventions
Participants
received TLNS (HFP or LFP) plus PT for a total of 14 weeks (2 in-clinic
and 12 at home), twice daily, followed by 12 weeks without treatment.
Main Outcome Measures
The
primary endpoint was change in SOT composite score from baseline to
week 14. Secondary variables (eg, Dynamic Gait Index [DGI], 6-minute
walk test [6MWT]) were also collected.
Results
Both arms had a significant (P<.0001)
improvement in SOT scores from baseline at weeks 2, 5, 14 (primary
endpoint), and 26. DGI scores had significant improvement (P<.001-.01)
from baseline at the same test points; 6MWT evaluations after 2 weeks
were significant. The SOT, DGI, and 6MWT scores did not significantly
differ between arms at any test point. There were no treatment-related
serious adverse events.
Conclusions
Both
the HFP+PT and LFP+PT groups had significantly improved balance scores,
and outcomes were sustained for 12 weeks after discontinuing TLNS
treatment. Results between arms did not significantly differ from each
other. Whether the 2 dosages are equally effective or whether
improvements are because of provision of PT cannot be conclusively
established at this time.
No comments:
Post a Comment