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Tuesday, March 17, 2020
Cranky people appeared better at fending off Alzheimer's disease. (Neurobiology of Aging)
Lower agreeableness is associated with better preservation of limbic areas.
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Aging-related hippocampal volume decrease is lower in elders with higher openness.
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Personality impact on brain volume is independent of amyloid load and APOE genotype.
Abstract
The
relationship between personality profiles and brain integrity in old
age is still a matter of debate. We examined the association between Big
Five factor and facet scores and MRI brain volume changes on a 54-month
follow-up in 65 elderly controls with 3 neurocognitive assessments
(baseline, 18 months, and 54 months), structural brain MRI (baseline and
54 months), brain amyloid PET during follow-up, and APOE genotyping.
Personality was assessed with the Neuroticism Extraversion Openness
Personality Inventory-Revised. Regression models were used to identify
predictors of volume loss including time, age, sex, personality, amyloid
load, presence of APOE ε4 allele, and cognitive evolution. Lower
agreeableness factor scores (and 4 of its facets) were associated with
lower volume loss in the hippocampus, entorhinal cortex, amygdala,
mesial temporal lobe, and precuneus bilaterally. Higher openness factor
scores (and 2 of its facets) were also associated with lower volume loss
in the left hippocampus. Our findings persisted when adjusting for
confounders in multivariable models. These data suggest that the
combination of low agreeableness and high openness is an independent
predictor of better preservation of brain volume in areas vulnerable to
neurodegeneration.
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