What the fuck is this trying to say? Should I be taking foods that create nitric oxide? What? How much? How often? Answers to those questions are what we need researchers to focus on. AND THAT IS WHY WE NEED SURVIVORS IN CHARGE. Nothing useful will get done otherwise. This is why reviews are useless.
Role of Nitric oxide in neurodegeneration: function, regulation and inhibition
Tewari D1, Sah AN2, Bawari S3, Nabavi SF4, Dehpour AR5, Shirooie S6, Braidy N7, Fiebich BL8, Vacca RA9, Nabavi SM4.
Abstract
Reactive
nitrogen species (RNS) and reactive oxygen species (ROS) collectively
known as reactive oxygen and nitrogen species (RONS) are the products of
normal cellular metabolism and interact with several vital biomolecules
including nucleic acid, proteins, and membrane lipids and alter their
function in an irreversible manner which can lead finally to cell death.
There is an imperative role for oxidative stress in the pathogenesis of
cognitive impairments and the development and progression of neural
injury. Elevated production of higher amounts of nitric oxide (NO) takes
place in numerous pathological conditions such as neurodegenerative
diseases, inflammation, and ischemia which occur concurrently with
elevated nitrosative/oxidative stress. The enzyme nitric oxide synthase
(NOS) is responsible for the generation of NO in different cells by
conversion of L-arginine (Arg) to L-citrulline. Therefore, the NO
signaling pathway represents a viable therapeutic target. Naturally
occurring polyphenols targeting the NO signaling pathway can be of major
importance in the field of neurodegeneration and related complications.
Here we comprehensively review the importance of NO and its production
in the human body and afterwards highlight the importance of various
natural products along with their mechanisms against various
neurodegenerative diseases involving their effect on NO production.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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