And with your muscle atrophy post stroke you need solutions. Hopefully your doctor is competent enough to have EXACT stroke protocols for that. S/he has had over 10 years to come up with a solution. Did they?

muscle atrophy (23 posts to July 2013)

A Review on the Mechanisms of Stroke-Induced Muscle Atrophy

Written By

Nicholas Bovio, Genevieve M. Abd, Jennifer C. Ku, Leah C. Liu and Yong Li

Submitted: 07 February 2024 Reviewed: 11 April 2024 Published: 16 May 2024

DOI: 10.5772/intechopen.114989

Human Physiology - Annual Volume 2024 Authored by Kunihiro Sakuma

From the Annual Volume

Human Physiology - Annual Volume 2024 [Working Title]

Prof. Kunihiro Sakuma and Dr. Kotomi Sakai

A Review on the Mechanisms of Stroke-Induced Muscle Atrophy | IntechOpen

Abstract

This comprehensive review elucidates the intricate, multifactorial pathophysiology underpinning post-stroke skeletal muscle atrophy, a detrimental complication impacting patient outcomes. Post-stroke complications including dysphagia, malabsorption, and inadequate protein intake precipitate a catabolic state, exacerbating muscle wasting. The dearth of essential amino acids perpetuates proteolysis over protein synthesis, highlighting the importance of nutritional interventions. Immobility-induced disuse atrophy and dysregulation of anabolic pathways, notably IGF/Akt/PI3K, favor proteolysis, disrupting muscle protein homeostasis. Proteolytic systems including the ubiquitin-proteasome pathway and autophagy play central roles. Moreover, transcriptomic alterations, insulin resistance, autonomic dysregulation, inflammation, oxidative stress, and dysregulated microRNAs contribute to reduced muscle mass post-stroke. Notably, matrix metalloproteinases’ (MMPs) implication unveils potential therapeutic avenues via MMP inhibition. Unraveling this complex pathophysiological interplay is crucial for developing multi-modal interventions to manage post-stroke muscle atrophy effectively.

Deans' stroke musings

Tuesday, May 21, 2024